Preservation of vision following cell-based therapies in a model of retinal degenerative disease

T. J. McGill; R. D. Lund; R. M. Douglas; S. Wang; B. Lu; G. T. Prusky

doi:10.1016/j.visres.2004.05.025

Preservation of vision following cell-based therapies in a model of retinal degenerative disease

T. J. McGill, R. D. Lund, R. M. Douglas, S. Wang, B. Lu, G. T. Prusky

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

This study examines whether subretinal transplantation of a human retinal pigment epithelial cell line (ARPE19) or human Schwann cells early in the course of degeneration can limit the loss of visual acuity that normally occurs in dystrophic Royal College of Surgeons (RCS) rats as they age. The acuity of both transplanted groups was significantly better than controls at all ages tested, though the rescue profile of each cell type was unique. These data indicate that the transplantation of cells with very different phenotypes can be used to limit the deterioration of spatial vision in an animal model of retinal degenerative disease.

Original language	English (US)
Pages (from-to)	2559-2566
Number of pages	8
Journal	Vision Research
Volume	44
Issue number	22
DOIs	https://doi.org/10.1016/j.visres.2004.05.025
State	Published - Oct 2004
Externally published	Yes

Keywords

Retinal dystrophy
Retinal pigment epithelium
Schwann cells
Transplantation
Visual acuity

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.visres.2004.05.025

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title = "Preservation of vision following cell-based therapies in a model of retinal degenerative disease",

abstract = "This study examines whether subretinal transplantation of a human retinal pigment epithelial cell line (ARPE19) or human Schwann cells early in the course of degeneration can limit the loss of visual acuity that normally occurs in dystrophic Royal College of Surgeons (RCS) rats as they age. The acuity of both transplanted groups was significantly better than controls at all ages tested, though the rescue profile of each cell type was unique. These data indicate that the transplantation of cells with very different phenotypes can be used to limit the deterioration of spatial vision in an animal model of retinal degenerative disease.",

keywords = "Retinal dystrophy, Retinal pigment epithelium, Schwann cells, Transplantation, Visual acuity",

author = "McGill, {T. J.} and Lund, {R. D.} and Douglas, {R. M.} and S. Wang and B. Lu and Prusky, {G. T.}",

note = "Funding Information: The authors would like to thank Dr. Patrick Wood for generously providing Schwann cells. This study was funded by grants from Foundation Fighting Blindness, NIH (EY14038), Wynn Foundation, Johnson and Johnson Focused Giving program and a grant to Moran Eye Center from Research to Prevent Blindness, and Natural Sciences and Engineering Research Council of Canada. ",

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AU - Lund, R. D.

AU - Douglas, R. M.

AU - Wang, S.

AU - Lu, B.

AU - Prusky, G. T.

N1 - Funding Information: The authors would like to thank Dr. Patrick Wood for generously providing Schwann cells. This study was funded by grants from Foundation Fighting Blindness, NIH (EY14038), Wynn Foundation, Johnson and Johnson Focused Giving program and a grant to Moran Eye Center from Research to Prevent Blindness, and Natural Sciences and Engineering Research Council of Canada.

PY - 2004/10

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AB - This study examines whether subretinal transplantation of a human retinal pigment epithelial cell line (ARPE19) or human Schwann cells early in the course of degeneration can limit the loss of visual acuity that normally occurs in dystrophic Royal College of Surgeons (RCS) rats as they age. The acuity of both transplanted groups was significantly better than controls at all ages tested, though the rescue profile of each cell type was unique. These data indicate that the transplantation of cells with very different phenotypes can be used to limit the deterioration of spatial vision in an animal model of retinal degenerative disease.

KW - Retinal dystrophy

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KW - Schwann cells

KW - Transplantation

KW - Visual acuity

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Preservation of vision following cell-based therapies in a model of retinal degenerative disease

Abstract

Keywords

ASJC Scopus subject areas

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