Preservation of vision following cell-based therapies in a model of retinal degenerative disease

Trevor McGill, R. D. Lund, R. M. Douglas, S. Wang, B. Lu, G. T. Prusky

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This study examines whether subretinal transplantation of a human retinal pigment epithelial cell line (ARPE19) or human Schwann cells early in the course of degeneration can limit the loss of visual acuity that normally occurs in dystrophic Royal College of Surgeons (RCS) rats as they age. The acuity of both transplanted groups was significantly better than controls at all ages tested, though the rescue profile of each cell type was unique. These data indicate that the transplantation of cells with very different phenotypes can be used to limit the deterioration of spatial vision in an animal model of retinal degenerative disease.

Original languageEnglish (US)
Pages (from-to)2559-2566
Number of pages8
JournalVision Research
Volume44
Issue number22
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Retinal Diseases
Cell- and Tissue-Based Therapy
Retinal Pigments
Schwann Cells
Cell Transplantation
Visual Acuity
Animal Models
Transplantation
Epithelial Cells
Phenotype
Cell Line
Surgeons

Keywords

  • Retinal dystrophy
  • Retinal pigment epithelium
  • Schwann cells
  • Transplantation
  • Visual acuity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Preservation of vision following cell-based therapies in a model of retinal degenerative disease. / McGill, Trevor; Lund, R. D.; Douglas, R. M.; Wang, S.; Lu, B.; Prusky, G. T.

In: Vision Research, Vol. 44, No. 22, 10.2004, p. 2559-2566.

Research output: Contribution to journalArticle

McGill, Trevor ; Lund, R. D. ; Douglas, R. M. ; Wang, S. ; Lu, B. ; Prusky, G. T. / Preservation of vision following cell-based therapies in a model of retinal degenerative disease. In: Vision Research. 2004 ; Vol. 44, No. 22. pp. 2559-2566.
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