Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cells

Mohamed Elrefaei, Chris A.R. Baker, Norman G. Jones, David R. Bangsberg, Huyen Cao

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Mechanisms leading to the observed immune dysregulation in HIV-1 infection are not well understood. HIV-specific IL-10-positive CD8+ T cells are increased in advanced HIV disease. We have previously reported that Gag-specific IL-10-positive CD8+ T cells suppressed cytolysis. In this study we describe the suppressive effect of Nef-specific IL-10-positive CD8+ T cells. Interestingly, simultaneous removal of both Gag- and Nef-specific IL-10-positive CD8+ T cells led to higher HIV-specific cytolysis compared with the removal of Nef-specific IL-10-positive CD8 + T cells alone. We also examined the level of programmed cell death-1 (PD-1) as a measure of immune dysfunction in association with IL-10-positive suppressor CD8+ T cells. The level of PD-1 expression on CD107-positive effector CD8+ T cells was significantly increased when IL-10-positive suppressor CD8+ T cells were present(p < 0.05). Our results suggest that IL-10-positive suppressor CD8+ T cells contribute to the immune dysfunction observed in advanced HIV infection and that the concomitant presence of multiple IL-10-positive CD8+ T cell populations may have an additive suppressive effect.

Original languageEnglish (US)
Pages (from-to)7757-7763
Number of pages7
JournalJournal of Immunology
Volume180
Issue number11
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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