Presence of suppressor HIV-specific CD8 + T cells is associated with increased PD-1 expression on effector CD8 + T cells

Mohamed Elrefaei, Chris A R Baker, Norman G. Jones, David Bangsberg, Huyen Cao

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Mechanisms leading to the observed immune dysregulation in HIV-1 infection are not well understood. HIV-specific IL-10-positive CD8 + T cells are increased in advanced HIV disease. We have previously reported that Gag-specific IL-10-positive CD8 + T cells suppressed cytolysis. In this study we describe the suppressive effect of Nef-specific IL-10-positive CD8 + T cells. Interestingly, simultaneous removal of both Gag- and Nef-specific IL-10-positive CD8 + T cells led to higher HIV-specific cytolysis compared with the removal of Nef-specific IL-10-positive CD8 + T cells alone. We also examined the level of programmed cell death-1 (PD-1) as a measure of immune dysfunction in association with IL-10-positive suppressor CD8 + T cells. The level of PD-1 expression on CD107-positive effector CD8 + T cells was significantly increased when IL-10-positive suppressor CD8 + T cells were present(p < 0.05). Our results suggest that IL-10-positive suppressor CD8 + T cells contribute to the immune dysfunction observed in advanced HIV infection and that the concomitant presence of multiple IL-10-positive CD8 + T cell populations may have an additive suppressive effect.

Original languageEnglish (US)
Pages (from-to)7757-7763
Number of pages7
JournalJournal of Immunology
Volume180
Issue number11
StatePublished - 2008
Externally publishedYes

Fingerprint

Interleukin-10
Cell Death
HIV
T-Lymphocytes
CD8-Positive T-Lymphocytes
HIV Infections
HIV-1
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Presence of suppressor HIV-specific CD8 + T cells is associated with increased PD-1 expression on effector CD8 + T cells. / Elrefaei, Mohamed; Baker, Chris A R; Jones, Norman G.; Bangsberg, David; Cao, Huyen.

In: Journal of Immunology, Vol. 180, No. 11, 2008, p. 7757-7763.

Research output: Contribution to journalArticle

Elrefaei, Mohamed ; Baker, Chris A R ; Jones, Norman G. ; Bangsberg, David ; Cao, Huyen. / Presence of suppressor HIV-specific CD8 + T cells is associated with increased PD-1 expression on effector CD8 + T cells. In: Journal of Immunology. 2008 ; Vol. 180, No. 11. pp. 7757-7763.
@article{01eca3a15d284459916c96430daddb6a,
title = "Presence of suppressor HIV-specific CD8 + T cells is associated with increased PD-1 expression on effector CD8 + T cells",
abstract = "Mechanisms leading to the observed immune dysregulation in HIV-1 infection are not well understood. HIV-specific IL-10-positive CD8 + T cells are increased in advanced HIV disease. We have previously reported that Gag-specific IL-10-positive CD8 + T cells suppressed cytolysis. In this study we describe the suppressive effect of Nef-specific IL-10-positive CD8 + T cells. Interestingly, simultaneous removal of both Gag- and Nef-specific IL-10-positive CD8 + T cells led to higher HIV-specific cytolysis compared with the removal of Nef-specific IL-10-positive CD8 + T cells alone. We also examined the level of programmed cell death-1 (PD-1) as a measure of immune dysfunction in association with IL-10-positive suppressor CD8 + T cells. The level of PD-1 expression on CD107-positive effector CD8 + T cells was significantly increased when IL-10-positive suppressor CD8 + T cells were present(p < 0.05). Our results suggest that IL-10-positive suppressor CD8 + T cells contribute to the immune dysfunction observed in advanced HIV infection and that the concomitant presence of multiple IL-10-positive CD8 + T cell populations may have an additive suppressive effect.",
author = "Mohamed Elrefaei and Baker, {Chris A R} and Jones, {Norman G.} and David Bangsberg and Huyen Cao",
year = "2008",
language = "English (US)",
volume = "180",
pages = "7757--7763",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "11",

}

TY - JOUR

T1 - Presence of suppressor HIV-specific CD8 + T cells is associated with increased PD-1 expression on effector CD8 + T cells

AU - Elrefaei, Mohamed

AU - Baker, Chris A R

AU - Jones, Norman G.

AU - Bangsberg, David

AU - Cao, Huyen

PY - 2008

Y1 - 2008

N2 - Mechanisms leading to the observed immune dysregulation in HIV-1 infection are not well understood. HIV-specific IL-10-positive CD8 + T cells are increased in advanced HIV disease. We have previously reported that Gag-specific IL-10-positive CD8 + T cells suppressed cytolysis. In this study we describe the suppressive effect of Nef-specific IL-10-positive CD8 + T cells. Interestingly, simultaneous removal of both Gag- and Nef-specific IL-10-positive CD8 + T cells led to higher HIV-specific cytolysis compared with the removal of Nef-specific IL-10-positive CD8 + T cells alone. We also examined the level of programmed cell death-1 (PD-1) as a measure of immune dysfunction in association with IL-10-positive suppressor CD8 + T cells. The level of PD-1 expression on CD107-positive effector CD8 + T cells was significantly increased when IL-10-positive suppressor CD8 + T cells were present(p < 0.05). Our results suggest that IL-10-positive suppressor CD8 + T cells contribute to the immune dysfunction observed in advanced HIV infection and that the concomitant presence of multiple IL-10-positive CD8 + T cell populations may have an additive suppressive effect.

AB - Mechanisms leading to the observed immune dysregulation in HIV-1 infection are not well understood. HIV-specific IL-10-positive CD8 + T cells are increased in advanced HIV disease. We have previously reported that Gag-specific IL-10-positive CD8 + T cells suppressed cytolysis. In this study we describe the suppressive effect of Nef-specific IL-10-positive CD8 + T cells. Interestingly, simultaneous removal of both Gag- and Nef-specific IL-10-positive CD8 + T cells led to higher HIV-specific cytolysis compared with the removal of Nef-specific IL-10-positive CD8 + T cells alone. We also examined the level of programmed cell death-1 (PD-1) as a measure of immune dysfunction in association with IL-10-positive suppressor CD8 + T cells. The level of PD-1 expression on CD107-positive effector CD8 + T cells was significantly increased when IL-10-positive suppressor CD8 + T cells were present(p < 0.05). Our results suggest that IL-10-positive suppressor CD8 + T cells contribute to the immune dysfunction observed in advanced HIV infection and that the concomitant presence of multiple IL-10-positive CD8 + T cell populations may have an additive suppressive effect.

UR - http://www.scopus.com/inward/record.url?scp=47249089060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47249089060&partnerID=8YFLogxK

M3 - Article

C2 - 18490780

AN - SCOPUS:47249089060

VL - 180

SP - 7757

EP - 7763

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 11

ER -