Preoptic area cooling increases the sympathetic outflow to brown adipose tissue and brown adipose tissue thermogenesis

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6 Citations (Scopus)

Abstract

Modest cold exposures are likely to activate autonomic thermogenic mechanisms due to activation of cutaneous thermal afferents, whereas central thermosensitive neurons set the background tone on which this afferent input is effective. In addition, more prolonged or severe cold exposures that overwhelm cold defense mechanisms would directly activate thermosensitive neurons within the central nervous system. Here, we examined the involvement of the canonical brown adipose tissue (BAT) sympathoexcitatory efferent pathway in the response to direct local cooling of the preoptic area (POA) in urethane-chloralose-anesthetized rats. With skin temperature and core body temperature maintained between 36 and 39°C, cooling POA temperature by ~1–4°C evoked increases in BAT sympathetic nerve activity (SNA), BAT temperature, expired CO2, and heart rate. POA cooling-evoked responses were inhibited by nanoinjections of ionotropic glutamate receptor antagonists or the GABAA receptor agonist muscimol into the median POA or by nanoinjections of ionotropic glutamate receptor antagonists into the dorsomedial hypothalamic nucleus (bilaterally) or into the raphe pallidus nucleus. These results demonstrate that direct cooling of the POA can increase BAT SNA and thermogenesis via the canonical BAT sympathoexcitatory efferent pathway, even in the face of warm thermal input from the skin and body core.

Original languageEnglish (US)
Pages (from-to)R609-R618
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume315
Issue number4
DOIs
StatePublished - Oct 1 2018

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Preoptic Area
Brown Adipose Tissue
Thermogenesis
Ionotropic Glutamate Receptors
Efferent Pathways
Excitatory Amino Acid Antagonists
Dorsomedial Hypothalamic Nucleus
Hot Temperature
GABA-A Receptor Agonists
Neurons
Muscimol
Skin
Chloralose
Temperature
Skin Temperature
Urethane
Body Temperature
Central Nervous System
Heart Rate

Keywords

  • Anterior hypothalamus
  • Dorsomedial hypothalamus
  • Metabolism
  • Thermoregulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

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title = "Preoptic area cooling increases the sympathetic outflow to brown adipose tissue and brown adipose tissue thermogenesis",
abstract = "Modest cold exposures are likely to activate autonomic thermogenic mechanisms due to activation of cutaneous thermal afferents, whereas central thermosensitive neurons set the background tone on which this afferent input is effective. In addition, more prolonged or severe cold exposures that overwhelm cold defense mechanisms would directly activate thermosensitive neurons within the central nervous system. Here, we examined the involvement of the canonical brown adipose tissue (BAT) sympathoexcitatory efferent pathway in the response to direct local cooling of the preoptic area (POA) in urethane-chloralose-anesthetized rats. With skin temperature and core body temperature maintained between 36 and 39°C, cooling POA temperature by ~1–4°C evoked increases in BAT sympathetic nerve activity (SNA), BAT temperature, expired CO2, and heart rate. POA cooling-evoked responses were inhibited by nanoinjections of ionotropic glutamate receptor antagonists or the GABAA receptor agonist muscimol into the median POA or by nanoinjections of ionotropic glutamate receptor antagonists into the dorsomedial hypothalamic nucleus (bilaterally) or into the raphe pallidus nucleus. These results demonstrate that direct cooling of the POA can increase BAT SNA and thermogenesis via the canonical BAT sympathoexcitatory efferent pathway, even in the face of warm thermal input from the skin and body core.",
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AU - Mohammed, Mazher

AU - Madden, Christopher (Chris)

AU - Burchiel, Kim

AU - Morrison, Shaun

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