Preoperative radiotherapy for adenocarcinoma of the rectosigmoid

Kenneth Stevens, C. V. Allen, W. S. Fletcher

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Ninety seven patients with adenocarcinoma of the rectosigmoid have been treated with high dose (5000-6000 rad) preoperative irradiation from 1960 through 1972 at the University of Oregon Health Sciences Center. Fifty seven were initially clinically resectable and 40 were initially inoperable. Forty of the 57 initially clinically resectable patients had 'curative' resections and are at risk for more than 5 years. An increase in 5 year survival (from 38% to 53%) and an absence of pelvic recurrence have occurred in those patients receiving preoperative irradiation and 'curative' resection. Four of the 40 initially inoperable patients are alive without tumor. Three of the four survivors had irradiation and surgery; one had irradiation only. An additional four patients had no evidence of tumor at death. Tumor was totally sterilized by irradiation in nine patients and reduced to microfocal extent in an additional three of the 97 patients. Incidence of complications was no greater than has been reported in a surgical series from the same institution.

Original languageEnglish (US)
Pages (from-to)2866-2874
Number of pages9
JournalCancer
Volume37
Issue number6
StatePublished - 1976

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Adenocarcinoma
Radiotherapy
Neoplasms
Survivors
Recurrence
Survival
Incidence
Health

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Stevens, K., Allen, C. V., & Fletcher, W. S. (1976). Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. Cancer, 37(6), 2866-2874.

Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. / Stevens, Kenneth; Allen, C. V.; Fletcher, W. S.

In: Cancer, Vol. 37, No. 6, 1976, p. 2866-2874.

Research output: Contribution to journalArticle

Stevens, K, Allen, CV & Fletcher, WS 1976, 'Preoperative radiotherapy for adenocarcinoma of the rectosigmoid', Cancer, vol. 37, no. 6, pp. 2866-2874.
Stevens K, Allen CV, Fletcher WS. Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. Cancer. 1976;37(6):2866-2874.
Stevens, Kenneth ; Allen, C. V. ; Fletcher, W. S. / Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. In: Cancer. 1976 ; Vol. 37, No. 6. pp. 2866-2874.
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