Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage

George Thomas, Matthew I. Schrage, Lisa Rosenfelt, Jin Hee Kim, Giri Salur, Jean B. DeKernion, Frederick Dorey, Jonathan Said, Robert E. Reiter

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Abstract

Purpose: Loss of p27 protein expression in radical prostatectomy specimens has been shown to be an adverse prognostic factor in patients with clinically localized prostate cancer. To our knowledge no studies have examined p27 expression in prostate needle biopsies. To test the potential predictive power of p27 in prostate biopsies we compared p27 expression in preoperative biopsies and matched prostatectomy specimens of patients with clinically localized prostate cancer. Materials and Methods: Matched biopsies and radical prostatectomy specimens from 44 patients were examined. Mean followup was 22.7 months (range 1 to 46). Tumors expressing less than 30% positive nuclei were classified as low expressors and tumors expressing greater than 30% positive nuclei were classified as high expressors of p27 protein. Results: Expression of p27 in prostate biopsies correlated significantly with subsequent p27 expression in radical prostatectomy specimens (p = 0.002). Sensitivity and specificity of biopsy p27 for predicting subsequent prostatectomy p27 were 87.5% and 88.9%, respectively (p <0.001). Univariate analysis showed that low expression of p27 in the biopsy correlated significantly with biopsy and prostatectomy Gleason score (p = 0.000 and 0.001, respectively), and final pathological stage (p = 0.028). Despite the small sample size and short followup, 36.4% of patients with low p27 expression had a biochemical recurrence compared to only 12.1% with high expression (hazards ratio 3.56). In addition, Kaplan-Meier analysis suggested that low p27 expression in prostate biopsies may be associated with a shorter time to recurrence, although this did not reach statistical significance (p = 0.081). Conclusions: Expression of p27 in prostate biopsies can be used to predict the degree of expression in radical prostatectomy specimens. As loss of p27 protein expression in prostatectomy specimens has been shown to correlate with biochemical recurrence and shortened prostate specific survival, these results suggest that biopsy p27 may help identify high risk patients preoperatively.

Original languageEnglish (US)
Pages (from-to)1987-1991
Number of pages5
JournalJournal of Urology
Volume164
Issue number6
StatePublished - 2000
Externally publishedYes

Fingerprint

Needle Biopsy
Prostatectomy
Prostate
Biopsy
Recurrence
Prostatic Neoplasms
Proteins
Neoplasm Grading
Kaplan-Meier Estimate
Sample Size
Neoplasms
Sensitivity and Specificity
Survival

Keywords

  • Biopsy
  • Genes
  • Prostatectomy
  • Prostatic neoplasms
  • Suppressor
  • Tumor

ASJC Scopus subject areas

  • Urology

Cite this

Thomas, G., Schrage, M. I., Rosenfelt, L., Kim, J. H., Salur, G., DeKernion, J. B., ... Reiter, R. E. (2000). Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage. Journal of Urology, 164(6), 1987-1991.

Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage. / Thomas, George; Schrage, Matthew I.; Rosenfelt, Lisa; Kim, Jin Hee; Salur, Giri; DeKernion, Jean B.; Dorey, Frederick; Said, Jonathan; Reiter, Robert E.

In: Journal of Urology, Vol. 164, No. 6, 2000, p. 1987-1991.

Research output: Contribution to journalArticle

Thomas, G, Schrage, MI, Rosenfelt, L, Kim, JH, Salur, G, DeKernion, JB, Dorey, F, Said, J & Reiter, RE 2000, 'Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage', Journal of Urology, vol. 164, no. 6, pp. 1987-1991.
Thomas, George ; Schrage, Matthew I. ; Rosenfelt, Lisa ; Kim, Jin Hee ; Salur, Giri ; DeKernion, Jean B. ; Dorey, Frederick ; Said, Jonathan ; Reiter, Robert E. / Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage. In: Journal of Urology. 2000 ; Vol. 164, No. 6. pp. 1987-1991.
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title = "Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage",
abstract = "Purpose: Loss of p27 protein expression in radical prostatectomy specimens has been shown to be an adverse prognostic factor in patients with clinically localized prostate cancer. To our knowledge no studies have examined p27 expression in prostate needle biopsies. To test the potential predictive power of p27 in prostate biopsies we compared p27 expression in preoperative biopsies and matched prostatectomy specimens of patients with clinically localized prostate cancer. Materials and Methods: Matched biopsies and radical prostatectomy specimens from 44 patients were examined. Mean followup was 22.7 months (range 1 to 46). Tumors expressing less than 30{\%} positive nuclei were classified as low expressors and tumors expressing greater than 30{\%} positive nuclei were classified as high expressors of p27 protein. Results: Expression of p27 in prostate biopsies correlated significantly with subsequent p27 expression in radical prostatectomy specimens (p = 0.002). Sensitivity and specificity of biopsy p27 for predicting subsequent prostatectomy p27 were 87.5{\%} and 88.9{\%}, respectively (p <0.001). Univariate analysis showed that low expression of p27 in the biopsy correlated significantly with biopsy and prostatectomy Gleason score (p = 0.000 and 0.001, respectively), and final pathological stage (p = 0.028). Despite the small sample size and short followup, 36.4{\%} of patients with low p27 expression had a biochemical recurrence compared to only 12.1{\%} with high expression (hazards ratio 3.56). In addition, Kaplan-Meier analysis suggested that low p27 expression in prostate biopsies may be associated with a shorter time to recurrence, although this did not reach statistical significance (p = 0.081). Conclusions: Expression of p27 in prostate biopsies can be used to predict the degree of expression in radical prostatectomy specimens. As loss of p27 protein expression in prostatectomy specimens has been shown to correlate with biochemical recurrence and shortened prostate specific survival, these results suggest that biopsy p27 may help identify high risk patients preoperatively.",
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T1 - Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, gleason grade and pathological stage

AU - Thomas, George

AU - Schrage, Matthew I.

AU - Rosenfelt, Lisa

AU - Kim, Jin Hee

AU - Salur, Giri

AU - DeKernion, Jean B.

AU - Dorey, Frederick

AU - Said, Jonathan

AU - Reiter, Robert E.

PY - 2000

Y1 - 2000

N2 - Purpose: Loss of p27 protein expression in radical prostatectomy specimens has been shown to be an adverse prognostic factor in patients with clinically localized prostate cancer. To our knowledge no studies have examined p27 expression in prostate needle biopsies. To test the potential predictive power of p27 in prostate biopsies we compared p27 expression in preoperative biopsies and matched prostatectomy specimens of patients with clinically localized prostate cancer. Materials and Methods: Matched biopsies and radical prostatectomy specimens from 44 patients were examined. Mean followup was 22.7 months (range 1 to 46). Tumors expressing less than 30% positive nuclei were classified as low expressors and tumors expressing greater than 30% positive nuclei were classified as high expressors of p27 protein. Results: Expression of p27 in prostate biopsies correlated significantly with subsequent p27 expression in radical prostatectomy specimens (p = 0.002). Sensitivity and specificity of biopsy p27 for predicting subsequent prostatectomy p27 were 87.5% and 88.9%, respectively (p <0.001). Univariate analysis showed that low expression of p27 in the biopsy correlated significantly with biopsy and prostatectomy Gleason score (p = 0.000 and 0.001, respectively), and final pathological stage (p = 0.028). Despite the small sample size and short followup, 36.4% of patients with low p27 expression had a biochemical recurrence compared to only 12.1% with high expression (hazards ratio 3.56). In addition, Kaplan-Meier analysis suggested that low p27 expression in prostate biopsies may be associated with a shorter time to recurrence, although this did not reach statistical significance (p = 0.081). Conclusions: Expression of p27 in prostate biopsies can be used to predict the degree of expression in radical prostatectomy specimens. As loss of p27 protein expression in prostatectomy specimens has been shown to correlate with biochemical recurrence and shortened prostate specific survival, these results suggest that biopsy p27 may help identify high risk patients preoperatively.

AB - Purpose: Loss of p27 protein expression in radical prostatectomy specimens has been shown to be an adverse prognostic factor in patients with clinically localized prostate cancer. To our knowledge no studies have examined p27 expression in prostate needle biopsies. To test the potential predictive power of p27 in prostate biopsies we compared p27 expression in preoperative biopsies and matched prostatectomy specimens of patients with clinically localized prostate cancer. Materials and Methods: Matched biopsies and radical prostatectomy specimens from 44 patients were examined. Mean followup was 22.7 months (range 1 to 46). Tumors expressing less than 30% positive nuclei were classified as low expressors and tumors expressing greater than 30% positive nuclei were classified as high expressors of p27 protein. Results: Expression of p27 in prostate biopsies correlated significantly with subsequent p27 expression in radical prostatectomy specimens (p = 0.002). Sensitivity and specificity of biopsy p27 for predicting subsequent prostatectomy p27 were 87.5% and 88.9%, respectively (p <0.001). Univariate analysis showed that low expression of p27 in the biopsy correlated significantly with biopsy and prostatectomy Gleason score (p = 0.000 and 0.001, respectively), and final pathological stage (p = 0.028). Despite the small sample size and short followup, 36.4% of patients with low p27 expression had a biochemical recurrence compared to only 12.1% with high expression (hazards ratio 3.56). In addition, Kaplan-Meier analysis suggested that low p27 expression in prostate biopsies may be associated with a shorter time to recurrence, although this did not reach statistical significance (p = 0.081). Conclusions: Expression of p27 in prostate biopsies can be used to predict the degree of expression in radical prostatectomy specimens. As loss of p27 protein expression in prostatectomy specimens has been shown to correlate with biochemical recurrence and shortened prostate specific survival, these results suggest that biopsy p27 may help identify high risk patients preoperatively.

KW - Biopsy

KW - Genes

KW - Prostatectomy

KW - Prostatic neoplasms

KW - Suppressor

KW - Tumor

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