Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum prostate specific antigen

Stephen J. Freedland, Martha K. Terris, George S. Csathy, Christopher J. Kane, Christopher Amling, Joseph C. Presti, Frederick Dorey, William J. Aronson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Purpose: We developed a preoperative model to risk stratify patients for prostate specific antigen (PSA) failure following radical prostatectomy (RP) and identify those at high risk who would be potential candidates for neoadjuvant clinical trials. Materials and Methods: A retrospective survey of 459 patients from the SEARCH Database treated with RP between 1990 and 2002 was done. Multivariate analysis was used to compare the preoperative variables of patient age, race, PSA, biopsy Gleason score, clinical stage and percent of prostate needle biopsy tissue with cancer for the ability to predict time to PSA recurrence following RP. Significant independent predictors were combined to create a novel risk grouping model. Results: On multivariate analysis biopsy Gleason score (p

Original languageEnglish (US)
Pages (from-to)2215-2220
Number of pages6
JournalJournal of Urology
Volume171
Issue number6 I
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Prostate-Specific Antigen
Prostatectomy
Neoplasm Grading
Biopsy
Recurrence
Multivariate Analysis
Serum
Neoplasms
Needle Biopsy
Prostate
Clinical Trials
Databases

Keywords

  • Prostate
  • Prostate-specific antigen
  • Prostatectomy
  • Prostatic neoplasms
  • Recurrence

ASJC Scopus subject areas

  • Urology

Cite this

Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum prostate specific antigen. / Freedland, Stephen J.; Terris, Martha K.; Csathy, George S.; Kane, Christopher J.; Amling, Christopher; Presti, Joseph C.; Dorey, Frederick; Aronson, William J.

In: Journal of Urology, Vol. 171, No. 6 I, 06.2004, p. 2215-2220.

Research output: Contribution to journalArticle

Freedland, Stephen J. ; Terris, Martha K. ; Csathy, George S. ; Kane, Christopher J. ; Amling, Christopher ; Presti, Joseph C. ; Dorey, Frederick ; Aronson, William J. / Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum prostate specific antigen. In: Journal of Urology. 2004 ; Vol. 171, No. 6 I. pp. 2215-2220.
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AU - Csathy, George S.

AU - Kane, Christopher J.

AU - Amling, Christopher

AU - Presti, Joseph C.

AU - Dorey, Frederick

AU - Aronson, William J.

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