Preoperative lateralization modalities for cushing Disease

Is Dynamic Magnetic Resonance Imaging or Cavernous Sinus Sampling More Predictive of Intraoperative Findings?

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective To analyze whether cavernous sinus sampling (CSS) and dynamic magnetic resonance imaging (dMRI) are consistent with intraoperative findings in Cushing disease (CD) patients. Design Retrospective outcomes study. Setting Oregon Health & Science University; 2006 and 2013. Participants A total of 37 CD patients with preoperative dMRI and CSS to confirm central adrenocorticotropic hormone (ACTH) hypersecretion. Patients were 78% female; mean age was 41 years (at diagnosis), and all had a minimum of 6 months of follow-up. Main Outcome Measures Correlations among patient characteristics, dMRI measurements, CSS results, and intraoperative findings. Results All CSS indicated presence of CD. Eight of 37 patients had no identifiable tumor on dMRI. Three of 37 patients had no tumor at surgery. dMRI tumor size was inversely correlated with age (rs=- 0.4; p=0.01) and directly correlated to intraoperative lateralization (rs=0.3; p

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalJournal of Neurological Surgery, Part B: Skull Base
Volume76
Issue number3
DOIs
StatePublished - Jun 1 2015

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Pituitary ACTH Hypersecretion
Cavernous Sinus
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Neoplasms
Adrenocorticotropic Hormone
Retrospective Studies
Health

Keywords

  • cavernous sinus sampling
  • Cushing disease
  • intraoperative lateralization
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

@article{78a3084fabcd431a991f72c713b602b2,
title = "Preoperative lateralization modalities for cushing Disease: Is Dynamic Magnetic Resonance Imaging or Cavernous Sinus Sampling More Predictive of Intraoperative Findings?",
abstract = "Objective To analyze whether cavernous sinus sampling (CSS) and dynamic magnetic resonance imaging (dMRI) are consistent with intraoperative findings in Cushing disease (CD) patients. Design Retrospective outcomes study. Setting Oregon Health & Science University; 2006 and 2013. Participants A total of 37 CD patients with preoperative dMRI and CSS to confirm central adrenocorticotropic hormone (ACTH) hypersecretion. Patients were 78{\%} female; mean age was 41 years (at diagnosis), and all had a minimum of 6 months of follow-up. Main Outcome Measures Correlations among patient characteristics, dMRI measurements, CSS results, and intraoperative findings. Results All CSS indicated presence of CD. Eight of 37 patients had no identifiable tumor on dMRI. Three of 37 patients had no tumor at surgery. dMRI tumor size was inversely correlated with age (rs=- 0.4; p=0.01) and directly correlated to intraoperative lateralization (rs=0.3; p",
keywords = "cavernous sinus sampling, Cushing disease, intraoperative lateralization, magnetic resonance imaging",
author = "Hai Sun and Yedinak, {Christine (Chris)} and Alp Ozpinar and Anderson, {James (Jim)} and Aclan Dogan and Johnny Delashaw and Maria Fleseriu",
year = "2015",
month = "6",
day = "1",
doi = "10.1055/s-0034-1543970",
language = "English (US)",
volume = "76",
pages = "218--224",
journal = "Journal of Neurological Surgery, Part B: Skull Base",
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T2 - Is Dynamic Magnetic Resonance Imaging or Cavernous Sinus Sampling More Predictive of Intraoperative Findings?

AU - Sun, Hai

AU - Yedinak, Christine (Chris)

AU - Ozpinar, Alp

AU - Anderson, James (Jim)

AU - Dogan, Aclan

AU - Delashaw, Johnny

AU - Fleseriu, Maria

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective To analyze whether cavernous sinus sampling (CSS) and dynamic magnetic resonance imaging (dMRI) are consistent with intraoperative findings in Cushing disease (CD) patients. Design Retrospective outcomes study. Setting Oregon Health & Science University; 2006 and 2013. Participants A total of 37 CD patients with preoperative dMRI and CSS to confirm central adrenocorticotropic hormone (ACTH) hypersecretion. Patients were 78% female; mean age was 41 years (at diagnosis), and all had a minimum of 6 months of follow-up. Main Outcome Measures Correlations among patient characteristics, dMRI measurements, CSS results, and intraoperative findings. Results All CSS indicated presence of CD. Eight of 37 patients had no identifiable tumor on dMRI. Three of 37 patients had no tumor at surgery. dMRI tumor size was inversely correlated with age (rs=- 0.4; p=0.01) and directly correlated to intraoperative lateralization (rs=0.3; p

AB - Objective To analyze whether cavernous sinus sampling (CSS) and dynamic magnetic resonance imaging (dMRI) are consistent with intraoperative findings in Cushing disease (CD) patients. Design Retrospective outcomes study. Setting Oregon Health & Science University; 2006 and 2013. Participants A total of 37 CD patients with preoperative dMRI and CSS to confirm central adrenocorticotropic hormone (ACTH) hypersecretion. Patients were 78% female; mean age was 41 years (at diagnosis), and all had a minimum of 6 months of follow-up. Main Outcome Measures Correlations among patient characteristics, dMRI measurements, CSS results, and intraoperative findings. Results All CSS indicated presence of CD. Eight of 37 patients had no identifiable tumor on dMRI. Three of 37 patients had no tumor at surgery. dMRI tumor size was inversely correlated with age (rs=- 0.4; p=0.01) and directly correlated to intraoperative lateralization (rs=0.3; p

KW - cavernous sinus sampling

KW - Cushing disease

KW - intraoperative lateralization

KW - magnetic resonance imaging

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