High‐dose preoperative irradiation with delayed disarticulation of an extremity involved with osteogenic sarcoma has resulted in a marked increase of tumor‐free survival in a small series of cases treated at the University of Oregon Medical School. Treatment was well tolerated without significant complications. The surgical specimen in most of the survivors contained no viable carcinoma after irradiation in the order of 10,000 rads. There is evidence that biopsy in suspected lesions should be performed without tourniquet to avoid flushing of the tumor cells from the marrow cavity. Discussion will include rationale for delayed surgery, possible influence of irradiation on immune factors, and techniques of irradiation.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 1973|
ASJC Scopus subject areas
- Cancer Research