TY - JOUR
T1 - Preoperative Gabapentin Administration and Its Impact on Postoperative Opioid Requirement and Pain in Sinonasal Surgery
AU - Gill, Amarbir S.
AU - Virani, Farrukh R.
AU - Hwang, Joshua C.
AU - Wilson, Machelle D.
AU - Beliveau, Angela M.
AU - Strong, E. Bradley
AU - Steele, Toby O.
N1 - Publisher Copyright:
© American Academy of Otolaryngology–Head and Neck Surgery Foundation 2020.
PY - 2021/4
Y1 - 2021/4
N2 - Objective: To determine the efficacy of preoperative gabapentin on patient-reported pain levels and postoperative opioid requirements following sinonasal surgery. Study Design: Retrospective review. Setting: Academic institution. Methods: Patients undergoing sinonasal surgery between July 2019 and January 2020 were followed. Groups were divided into those that received 600 mg of oral gabapentin 1 hour preoperatively (gabapentin) and those that did not (control). Postoperatively, each patient was counseled to use acetaminophen, ibuprofen, and oxycodone as needed for pain control. Patients completed a daily postoperative pain and medication log. Pain was measured by the visual analog scale (VAS) and opioid use by morphine equivalent dose (MED). Chi-square test and Wilcoxon test were used for data analysis. Results: Fifty-seven patients were included (control, n = 28; gabapentin, n = 29). There was no significant difference in age, sex, or baseline Sinonasal Outcome Test–22 scores between the groups. The total MED, postoperative day (POD) 1-2 MED, POD 3-4 MED, and POD 5-6 MED did not differ significantly between the control (17.9, 12.2, 4.6, 1.5) and gabapentin (19.0, 8.9, 7.2, 3.5) groups (P =.98,.25,.16,.44). The mean daily VAS score did not differ significantly between the control (3.1) and gabapentin (2.8) groups (P =.81). The mean daily VAS score decreased significantly in both groups with each successive POD (P =.004). Conclusion: Preoperative gabapentin did not significantly reduce postoperative pain or opioid use. Postoperative discomfort following sinonasal surgery is mild, and opioid intake is minimal.
AB - Objective: To determine the efficacy of preoperative gabapentin on patient-reported pain levels and postoperative opioid requirements following sinonasal surgery. Study Design: Retrospective review. Setting: Academic institution. Methods: Patients undergoing sinonasal surgery between July 2019 and January 2020 were followed. Groups were divided into those that received 600 mg of oral gabapentin 1 hour preoperatively (gabapentin) and those that did not (control). Postoperatively, each patient was counseled to use acetaminophen, ibuprofen, and oxycodone as needed for pain control. Patients completed a daily postoperative pain and medication log. Pain was measured by the visual analog scale (VAS) and opioid use by morphine equivalent dose (MED). Chi-square test and Wilcoxon test were used for data analysis. Results: Fifty-seven patients were included (control, n = 28; gabapentin, n = 29). There was no significant difference in age, sex, or baseline Sinonasal Outcome Test–22 scores between the groups. The total MED, postoperative day (POD) 1-2 MED, POD 3-4 MED, and POD 5-6 MED did not differ significantly between the control (17.9, 12.2, 4.6, 1.5) and gabapentin (19.0, 8.9, 7.2, 3.5) groups (P =.98,.25,.16,.44). The mean daily VAS score did not differ significantly between the control (3.1) and gabapentin (2.8) groups (P =.81). The mean daily VAS score decreased significantly in both groups with each successive POD (P =.004). Conclusion: Preoperative gabapentin did not significantly reduce postoperative pain or opioid use. Postoperative discomfort following sinonasal surgery is mild, and opioid intake is minimal.
KW - chronic pain
KW - chronic rhinosinusitis
KW - gabapentin
KW - migraine
KW - morphine equivalent dosing
KW - postoperative pain
KW - sinonasal surgery
KW - visual analog scale
UR - http://www.scopus.com/inward/record.url?scp=85090458393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090458393&partnerID=8YFLogxK
U2 - 10.1177/0194599820952805
DO - 10.1177/0194599820952805
M3 - Article
AN - SCOPUS:85090458393
SN - 0194-5998
VL - 164
SP - 889
EP - 894
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
IS - 4
ER -