Preoperative criteria predictive of late survival following valve replacement for severe aortic regurgitation

John Greves, Shahbudin H. Rahimtoola, John H. McAnulty, Henry DeMots, David G. Clark, Barry Greenberg, Albert Starr

Research output: Contribution to journalArticle

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Abstract

Forty-five patients underwent aortic valve replacement (AVR) for severe isolated aortic regurgitation from 1973 to 1979. There were two (4.4%) hospital deaths, both functional class IV. Six patients with mechanical prosthesis not receiving anticoagulants were excluded from further analysis. These data relate to 39 patients; the two operative deaths, 35 patients with mechanical prosthesis receiving anticoagulants, and two with bioprosthesis. There were three late cardiac deaths with 5-year survival 85%; average annual mortality rate of 3%. The 5-year survival with pre-AVR left ventricular (LV) ejection fraction ≥ 0.45 was 87% vs 54% <0.45, (p <0.04); cardiac index ≥ 2.5 L/min/m2 92% vs 66% <2.5 (p <0.04); mean VCF ≥ 0.75 vs <0.75 circ/sec (p <0.09); end-diastolic pressure ≤ 20 vs > 20 mm Hg (p <0.08). Late survival was not significantly different between pre-AVR functional class I and II vs class III and IV; LV end-diastolic volume index ≥ 210 vs <210 ml/m2; LV end-systolic volume index ≥ 110 vs <110 ml/m2; and LV mass ≥ 240 vs <240 gm/m2. With ejection fraction ≥ 0.50 there was only one operative death (functional class IV) and no late cardiac deaths. Thus late survival following aortic valve replacement for severe isolated aortic regurgitation is better predicted preoperatively by the LV systolic pump function variables of ejection fraction and cardiac index than by LV diastolic parameters and clinical status.

Original languageEnglish (US)
Pages (from-to)300-308
Number of pages9
JournalAmerican Heart Journal
Volume101
Issue number3
DOIs
StatePublished - 1981

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Aortic Valve Insufficiency
Aortic Valve
Survival
Stroke Volume
Anticoagulants
Prostheses and Implants
Bioprosthesis
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Greves, J., Rahimtoola, S. H., McAnulty, J. H., DeMots, H., Clark, D. G., Greenberg, B., & Starr, A. (1981). Preoperative criteria predictive of late survival following valve replacement for severe aortic regurgitation. American Heart Journal, 101(3), 300-308. https://doi.org/10.1016/0002-8703(81)90194-0

Preoperative criteria predictive of late survival following valve replacement for severe aortic regurgitation. / Greves, John; Rahimtoola, Shahbudin H.; McAnulty, John H.; DeMots, Henry; Clark, David G.; Greenberg, Barry; Starr, Albert.

In: American Heart Journal, Vol. 101, No. 3, 1981, p. 300-308.

Research output: Contribution to journalArticle

Greves, J, Rahimtoola, SH, McAnulty, JH, DeMots, H, Clark, DG, Greenberg, B & Starr, A 1981, 'Preoperative criteria predictive of late survival following valve replacement for severe aortic regurgitation', American Heart Journal, vol. 101, no. 3, pp. 300-308. https://doi.org/10.1016/0002-8703(81)90194-0
Greves, John ; Rahimtoola, Shahbudin H. ; McAnulty, John H. ; DeMots, Henry ; Clark, David G. ; Greenberg, Barry ; Starr, Albert. / Preoperative criteria predictive of late survival following valve replacement for severe aortic regurgitation. In: American Heart Journal. 1981 ; Vol. 101, No. 3. pp. 300-308.
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