Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: Is it fffective?

Waralak Yamasmit, Surasith Chaithongwongwatthana, Jorge E. Tolosa

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

OBJECTIVE: To summarize current knowledge on whether prenatal prophylactic vitamin K1 administration to epileptic women receiving enzyme-inducing antiepileptic drugs (AEDs) to prevent neonatal hemorrhage is effective. STUDY DESIGN: A computerized MEDLINE search was conducted using the terms antiepileptic drug, hemorrhagic disease of the newborn, pregnancy and vitamin K since 1966 to July 2004, limited only to human studies. English-language publications were selected based on their relevance to the clinical effectiveness of administration of oral vitamin K to epileptic women exposed to enzyme-inducing AEDs for prevention of hemorrhagic disease of the newborn (HDN). RESULTS: No randomized, controlled trial testing prenatal vitamin K1 administration for reducing the incidence or severity of neonatal hemorrhage was identified. This review summarizes the data from published observational studies. CONCLUSION: There is inadequate evidence to recommend the routine administration of prenatal vitamin K to epileptic women exposed to enzyme-inducing AED therapy in order to prevent HDN.

Original languageEnglish (US)
Pages (from-to)463-466
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume51
Issue number6
StatePublished - Jun 1 2006

Keywords

  • Epilepsy
  • Hemorrhagic disease of newborn
  • Vitamin K1

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: Is it fffective?'. Together they form a unique fingerprint.

  • Cite this