Premature menopause in survivors of childhood cancer: A report from the childhood cancer survivor study

Charles A. Sklar, Ann C. Mertens, Pauline Mitby, John Whitton, Marilyn Stovall, Catherine Kasper, Jean Mulder, Daniel Green, H. Stacy Nicholson, Yutaka Yasui, Leslie L. Robison

Research output: Contribution to journalArticle

351 Scopus citations


Background: Childhood cancer survivors who retain ovarian function after completing cancer treatment are at increased risk of developing premature menopause, defined as cessation of menses before age 40 years. However, published data pertaining to the risk and frequency of premature menopause are limited. Methods: We assessed the incidence of and risk factors for premature menopause in 2819 survivors of childhood cancer who were older than 18 years and were participants in the multicenter Childhood Cancer Survivor Study (CCSS). The comparison group was 1065 female siblings of participants in the CCSS. A multiple Poisson regression model was constructed to determine risk factors for nonsurgical premature menopause. All statistical tests were two-sided. Results: A total of 126 childhood cancer survivors and 33 control siblings developed premature menopause. Of these women, 61 survivors (48%) and 31 siblings (94%) had surgically induced menopause (rate ratio [RR] = 0.8, 95% confidence interval [CI] = 0.52 to 1.23). However, the cumulative incidence of nonsurgical premature menopause was higher for survivors than for siblings (8% versus 0.8%; RR = 13.21, 95% CI = 3.26 to 53.51; P

Original languageEnglish (US)
Pages (from-to)890-896
Number of pages7
JournalJournal of the National Cancer Institute
Issue number13
Publication statusPublished - Jul 5 2006


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sklar, C. A., Mertens, A. C., Mitby, P., Whitton, J., Stovall, M., Kasper, C., ... Robison, L. L. (2006). Premature menopause in survivors of childhood cancer: A report from the childhood cancer survivor study. Journal of the National Cancer Institute, 98(13), 890-896.