Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus

Yu Asanuma, Annette Oeser, Ayumi K. Shintani, Elizabeth Turner, Nancy Olsen, Sergio Fazio, MacRae F. Linton, Paolo Raggi, C. Michael Stein

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Premature coronary artery disease is a major cause of illness and death in patients with systemic lupus erythematosus, but little is known about the prevalence, extent and causes of coronary-artery atherosclerosis. METHODS: We used electron-beam computed tomography to screen for the presence of coronary-artery calcification in 65 patients with systemic lupus erythematosus (mean [±SD] age, 40.3±11.6 years) and 69 control subjects (mean age, 42.7±12.6 years) with no history of coronary artery disease. When calcification was detected, the extent was measured by means of the Agatston score. The frequency of risk factors for coronary artery disease was compared in patients and controls, and the relation between the patients' clinical characteristics and the presence or absence of coronary-artery calcification was examined. RESULTS: The two groups were similar with respect to age, race, and sex. Coronary-artery calcification was more frequent in patients with lupus (20 of 65 patients) than in control subjects (6 of 69 subjects) (P=0.002). The mean calcification score was 68.9±244.2 in the patients and 8.8±41.8 (P

Original languageEnglish (US)
Pages (from-to)2407-2415
Number of pages9
JournalNew England Journal of Medicine
Volume349
Issue number25
DOIs
StatePublished - Dec 18 2003
Externally publishedYes

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Systemic Lupus Erythematosus
Coronary Artery Disease
Coronary Vessels
X Ray Computed Tomography
Cause of Death

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Asanuma, Y., Oeser, A., Shintani, A. K., Turner, E., Olsen, N., Fazio, S., ... Stein, C. M. (2003). Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus. New England Journal of Medicine, 349(25), 2407-2415. https://doi.org/10.1056/NEJMoa035611

Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus. / Asanuma, Yu; Oeser, Annette; Shintani, Ayumi K.; Turner, Elizabeth; Olsen, Nancy; Fazio, Sergio; Linton, MacRae F.; Raggi, Paolo; Stein, C. Michael.

In: New England Journal of Medicine, Vol. 349, No. 25, 18.12.2003, p. 2407-2415.

Research output: Contribution to journalArticle

Asanuma, Y, Oeser, A, Shintani, AK, Turner, E, Olsen, N, Fazio, S, Linton, MF, Raggi, P & Stein, CM 2003, 'Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus', New England Journal of Medicine, vol. 349, no. 25, pp. 2407-2415. https://doi.org/10.1056/NEJMoa035611
Asanuma, Yu ; Oeser, Annette ; Shintani, Ayumi K. ; Turner, Elizabeth ; Olsen, Nancy ; Fazio, Sergio ; Linton, MacRae F. ; Raggi, Paolo ; Stein, C. Michael. / Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus. In: New England Journal of Medicine. 2003 ; Vol. 349, No. 25. pp. 2407-2415.
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