Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph

C. Woody, D. Schlyer, P. Vaska, D. Tomasi, S. Solis-Najera, William Rooney, J. F. Pratte, S. Junnarkar, S. Stoll, Z. Master, M. Purschke, S. J. Park, S. Southekal, A. Kriplani, S. Krishnamoorthy, S. Maramraju, P. O'Connor, V. Radeka

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We are developing a scanner that will allow simultaneous acquisition of high resolution anatomical data using magnetic resonance imaging (MRI) and quantitative physiological data using positron emission tomography (PET). The approach is based on the technology used for the RatCAP conscious small animal PET tomograph which utilizes block detectors consisting of pixelated arrays of LSO crystals read out with matching arrays of avalanche photodiodes and a custom-designed ASIC. The version of this detector used for simultaneous PET/MRI imaging will be constructed out of all nonmagnetic materials and will be situated inside the MRI field. We have demonstrated that the PET detector and its electronics can be operated inside the MRI, and have obtained MRI images with various detector components located inside the MRI field. The MRI images show minimal distortion in this configuration even where some components still contain traces of certain magnetic materials. We plan to improve on the image quality in the future using completely non-magnetic components and by tuning the MRI pulse sequences. The combined result will be a highly compact, low mass PET scanner that can operate inside an MRI magnet without distorting the MRI image, and can be retrofitted into existing MRI instruments.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume571
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - Feb 1 2007

Fingerprint

Positron emission tomography
Magnetic resonance
scanners
magnetic resonance
animals
positrons
Animals
tomography
Imaging techniques
Detectors
detectors
application specific integrated circuits
Avalanche photodiodes
Magnetic materials
magnetic materials
Application specific integrated circuits
avalanches
photodiodes
Image quality
acquisition

Keywords

  • PET
  • PET/MRI
  • RatCAP
  • Simultaneous PET/MRI

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

Cite this

Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph. / Woody, C.; Schlyer, D.; Vaska, P.; Tomasi, D.; Solis-Najera, S.; Rooney, William; Pratte, J. F.; Junnarkar, S.; Stoll, S.; Master, Z.; Purschke, M.; Park, S. J.; Southekal, S.; Kriplani, A.; Krishnamoorthy, S.; Maramraju, S.; O'Connor, P.; Radeka, V.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 571, No. 1-2 SPEC. ISS., 01.02.2007, p. 102-105.

Research output: Contribution to journalArticle

Woody, C, Schlyer, D, Vaska, P, Tomasi, D, Solis-Najera, S, Rooney, W, Pratte, JF, Junnarkar, S, Stoll, S, Master, Z, Purschke, M, Park, SJ, Southekal, S, Kriplani, A, Krishnamoorthy, S, Maramraju, S, O'Connor, P & Radeka, V 2007, 'Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 571, no. 1-2 SPEC. ISS., pp. 102-105. https://doi.org/10.1016/j.nima.2006.10.039
Woody, C. ; Schlyer, D. ; Vaska, P. ; Tomasi, D. ; Solis-Najera, S. ; Rooney, William ; Pratte, J. F. ; Junnarkar, S. ; Stoll, S. ; Master, Z. ; Purschke, M. ; Park, S. J. ; Southekal, S. ; Kriplani, A. ; Krishnamoorthy, S. ; Maramraju, S. ; O'Connor, P. ; Radeka, V. / Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph. In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2007 ; Vol. 571, No. 1-2 SPEC. ISS. pp. 102-105.
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