Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph

D. Schlyer; P. Vaska; D. Tomasi; C. Woody; S. Solis-Najera; S. Southekal; W. Rooney; J. F. Pratte; S. Junnarkar; S. Stoll; M. Purschke; S. J. Park; Z. Master; S. H. Maramraju; S. Krishnamoorthy; A. Kriplani; W. Schiffer; P. O'Connor

doi:10.1109/NSSMIC.2006.354383

Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph

D. Schlyer, P. Vaska, D. Tomasi, C. Woody, S. Solis-Najera, S. Southekal, W. Rooney, J. F. Pratte, S. Junnarkar, S. Stoll, M. Purschke, S. J. Park, Z. Master, S. H. Maramraju, S. Krishnamoorthy, A. Kriplani, W. Schiffer, P. O'Connor

Advanced Imaging Research Center

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

9 Scopus citations

Abstract

We are developing a scanner that will allow the simultaneous acquisition of high resolution anatomical data using Magnetic Resonance Imaging (MRI) and quantitative physiological data using Positron Emission Tomography (PET). The approach is based on the technology used for the RatCAP conscious small animal PET tomograph which utilizes block detectors consisting of pixelated arrays of LSO crystals read out with matching arrays of avalanche photodiodes (APDs) and a custom-designed ASIC. A version of the detector is being developed that will be constructed out of all non-magnetic materials that can be operated inside the MRI field. We have demonstrated that the PET detector works inside the MRI field using 511 keV gamma rays, and have obtained MRI images with various detector components that show minimal distortion in the MRI image. We plan to improve on the image quality in the future using completely non-magnetic components and by tuning the MRI pulse sequences. The combined result will be a highly compact, low mass PET scanner that can operate inside an MRI magnet without distorting the MRI image, and can be retrofitted into existing MRI instruments.

Original language	English (US)
Title of host publication	2006 IEEE Nuclear Science Symposium - Conference Record
Pages	2340-2344
Number of pages	5
DOIs	https://doi.org/10.1109/NSSMIC.2006.354383
State	Published - 2007
Event	2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States Duration: Oct 29 2006 → Nov 4 2006

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Volume	4
ISSN (Print)	1095-7863

Other

Other	2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Country/Territory	United States
City	San Diego, CA
Period	10/29/06 → 11/4/06

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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10.1109/NSSMIC.2006.354383

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Schlyer, D., Vaska, P., Tomasi, D., Woody, C., Solis-Najera, S., Southekal, S., Rooney, W., Pratte, J. F., Junnarkar, S., Stoll, S., Purschke, M., Park, S. J., Master, Z., Maramraju, S. H., Krishnamoorthy, S., Kriplani, A., Schiffer, W., & O'Connor, P. (2007). Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 2340-2344). Article 4179497 (IEEE Nuclear Science Symposium Conference Record; Vol. 4). https://doi.org/10.1109/NSSMIC.2006.354383

Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph. / Schlyer, D.; Vaska, P.; Tomasi, D. et al.
2006 IEEE Nuclear Science Symposium - Conference Record. 2007. p. 2340-2344 4179497 (IEEE Nuclear Science Symposium Conference Record; Vol. 4).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Schlyer, D, Vaska, P, Tomasi, D, Woody, C, Solis-Najera, S, Southekal, S, Rooney, W, Pratte, JF, Junnarkar, S, Stoll, S, Purschke, M, Park, SJ, Master, Z, Maramraju, SH, Krishnamoorthy, S, Kriplani, A, Schiffer, W & O'Connor, P 2007, Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph. in 2006 IEEE Nuclear Science Symposium - Conference Record., 4179497, IEEE Nuclear Science Symposium Conference Record, vol. 4, pp. 2340-2344, 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD, San Diego, CA, United States, 10/29/06. https://doi.org/10.1109/NSSMIC.2006.354383

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abstract = "We are developing a scanner that will allow the simultaneous acquisition of high resolution anatomical data using Magnetic Resonance Imaging (MRI) and quantitative physiological data using Positron Emission Tomography (PET). The approach is based on the technology used for the RatCAP conscious small animal PET tomograph which utilizes block detectors consisting of pixelated arrays of LSO crystals read out with matching arrays of avalanche photodiodes (APDs) and a custom-designed ASIC. A version of the detector is being developed that will be constructed out of all non-magnetic materials that can be operated inside the MRI field. We have demonstrated that the PET detector works inside the MRI field using 511 keV gamma rays, and have obtained MRI images with various detector components that show minimal distortion in the MRI image. We plan to improve on the image quality in the future using completely non-magnetic components and by tuning the MRI pulse sequences. The combined result will be a highly compact, low mass PET scanner that can operate inside an MRI magnet without distorting the MRI image, and can be retrofitted into existing MRI instruments.",

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Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph

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