Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia

Britta Torgrimson-Ojerio, Rebecca L. Ross, Nathan Dieckmann, Stephanie Avery, Robert (Rob) Bennett, Kim Jones, Anthony J. Guarino, Lisa Wood

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Exercise intolerance, as evidenced by a worsening of pain, fatigue, and stiffness after novel exertion, is a key feature of fibromyalgia (FM). In this pilot study, we investigate whether; insufficient muscle repair processes and impaired anti-inflammatory mechanisms result in an exaggerated pro-inflammatory cytokine response to exhaustive exercise, and consequently a worsening of muscle pain, stiffness and fatigue in the days post-exercise. We measured changes in muscle pain and tenderness, fatigue, stiffness, and serum levels of neuroendocrine and inflammatory cytokine markers in 20 women with FM and 16 healthy controls (HCs) before and after exhaustive treadmill exercise. Compared to HCs, FM participants failed to mount the expected anti-inflammatory response to exercise and experienced a worsening of symptoms post-exercise. However, changes in post-exertional symptoms were not mediated by post-exertional changes in pro-inflammatory cytokine levels. Implications of these findings are discussed.

    Original languageEnglish (US)
    Pages (from-to)160-167
    Number of pages8
    JournalJournal of Neuroimmunology
    Volume277
    Issue number1-2
    DOIs
    StatePublished - Dec 15 2014

    Fingerprint

    Fibromyalgia
    Anti-Inflammatory Agents
    Exercise
    Myalgia
    Cytokines
    Fatigue
    Muscle Fatigue
    Pain
    Muscles
    Serum

    Keywords

    • Cortisol
    • Cytokine
    • Exercise
    • Fatigue
    • Fibromyalgia
    • Stiffness

    ASJC Scopus subject areas

    • Immunology
    • Clinical Neurology
    • Immunology and Allergy
    • Neurology

    Cite this

    Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia. / Torgrimson-Ojerio, Britta; Ross, Rebecca L.; Dieckmann, Nathan; Avery, Stephanie; Bennett, Robert (Rob); Jones, Kim; Guarino, Anthony J.; Wood, Lisa.

    In: Journal of Neuroimmunology, Vol. 277, No. 1-2, 15.12.2014, p. 160-167.

    Research output: Contribution to journalArticle

    Torgrimson-Ojerio, B, Ross, RL, Dieckmann, N, Avery, S, Bennett, RR, Jones, K, Guarino, AJ & Wood, L 2014, 'Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia', Journal of Neuroimmunology, vol. 277, no. 1-2, pp. 160-167. https://doi.org/10.1016/j.jneuroim.2014.10.003
    Torgrimson-Ojerio, Britta ; Ross, Rebecca L. ; Dieckmann, Nathan ; Avery, Stephanie ; Bennett, Robert (Rob) ; Jones, Kim ; Guarino, Anthony J. ; Wood, Lisa. / Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia. In: Journal of Neuroimmunology. 2014 ; Vol. 277, No. 1-2. pp. 160-167.
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