Preimplantation genetic diagnosis.

N. Ouhibi, Susan Olson, Phillip Patton, D. Wolf

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Preimplantation genetic diagnosis (PGD) has now been used in human fertility centers for a decade. To this end, diagnostic analysis is conducted on polar bodies or single blastomeres from biopsied embryos before the embryos are transferred, allowing the selection of normal embryos before a pregnancy has been established. Advances in technology available for PGD are described, including fluorescent in situ hybridization (FISH), interphase chromosome conversion, comparative genomic hybridization (CGH), fluorescent polymerase chain reaction (PCR), multiplex PCR, and whole genome amplification. These techniques support the diagnosis of a number of diseases at the single-cell level.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalCurrent women"s health reports
Volume1
Issue number2
StatePublished - Oct 2001

Fingerprint

Preimplantation Diagnosis
Embryonic Structures
Polar Bodies
Blastomeres
Comparative Genomic Hybridization
Multiplex Polymerase Chain Reaction
Interphase
Fluorescence In Situ Hybridization
Fertility
Chromosomes
Genome
Technology
Pregnancy
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Preimplantation genetic diagnosis. / Ouhibi, N.; Olson, Susan; Patton, Phillip; Wolf, D.

In: Current women"s health reports, Vol. 1, No. 2, 10.2001, p. 138-142.

Research output: Contribution to journalArticle

Ouhibi, N, Olson, S, Patton, P & Wolf, D 2001, 'Preimplantation genetic diagnosis.', Current women"s health reports, vol. 1, no. 2, pp. 138-142.
Ouhibi, N. ; Olson, Susan ; Patton, Phillip ; Wolf, D. / Preimplantation genetic diagnosis. In: Current women"s health reports. 2001 ; Vol. 1, No. 2. pp. 138-142.
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