Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification

Cyril Ramathal, Renee A. Reijo Pera, Shawn Chavez

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Citation (Scopus)

    Abstract

    Embryo development in mammals begins at fertilization with migration and fusion of the gametic pronuclei and extensive genome-wide epigenetic remodeling. The hallmark of preimplantation development is the transition from gametic to embryonic differentiation programs. Information that functionally specifies germ cells must be degraded while those required by the nascent embryo are expressed for the first time. Unique gene expression and epigenetic patterning also provides the foundation for differentiation of somatic and germ cell lineages. This chapter reviews fundamentals of epigenetic reprogramming, genetic (chromosomal) instability, timing, and mechanisms of embryonic gene activation, compaction, and cavitation. We discuss lineage specification beginning with trophectoderm, then focus on allocation of the germ line, and move toward development of germ cells from pluripotent stem cells. Finally, we conclude by discussing how current knowledge of embryogenesis and pluripotent stem cell biology may be applied to assisted reproduction and regenerative medicine now and in the future.

    Original languageEnglish (US)
    Title of host publicationKnobil and Neill's Physiology of Reproduction: Two-Volume Set
    PublisherElsevier Inc.
    Pages233-265
    Number of pages33
    Volume1
    ISBN (Print)9780123977694, 9780123971753
    DOIs
    StatePublished - Dec 23 2014

    Fingerprint

    Cell Lineage
    Germ Cells
    Embryonic Development
    Epigenomics
    Pluripotent Stem Cells
    Chromosomal Instability
    Regenerative Medicine
    Fertilization
    Transcriptional Activation
    Reproduction
    Cell Biology
    Mammals
    Embryonic Structures
    Genome
    Gene Expression

    Keywords

    • Embryo
    • Embryogenesis
    • Gametogenesis
    • Germ cell
    • IVF
    • Preimplantation
    • Stem cell
    • Transplantation

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Ramathal, C., Reijo Pera, R. A., & Chavez, S. (2014). Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification. In Knobil and Neill's Physiology of Reproduction: Two-Volume Set (Vol. 1, pp. 233-265). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397175-3.00006-5

    Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification. / Ramathal, Cyril; Reijo Pera, Renee A.; Chavez, Shawn.

    Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 1 Elsevier Inc., 2014. p. 233-265.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Ramathal, C, Reijo Pera, RA & Chavez, S 2014, Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification. in Knobil and Neill's Physiology of Reproduction: Two-Volume Set. vol. 1, Elsevier Inc., pp. 233-265. https://doi.org/10.1016/B978-0-12-397175-3.00006-5
    Ramathal C, Reijo Pera RA, Chavez S. Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification. In Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 1. Elsevier Inc. 2014. p. 233-265 https://doi.org/10.1016/B978-0-12-397175-3.00006-5
    Ramathal, Cyril ; Reijo Pera, Renee A. ; Chavez, Shawn. / Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification. Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 1 Elsevier Inc., 2014. pp. 233-265
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