Pregnancy outcome in thoracic aortic disease data from the Registry of Pregnancy and Cardiac disease

Laurence Campens, Lucia Baris, Nandita S. Scott, Craig S. Broberg, Antione Bondue, Guillaume Jondeau, Jasmine Grewal, Mark R. Johnson, Roger Hall, Julie De Backer, Jolien W. Roos-Hesselink

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations


    Background Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is considered a high risk period in women with underlying aortopathy. Methods The ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective global registry that enrolled 5739 women with pre-existing cardiac disease. With this analysis, we aim to study the maternal and fetal outcome of pregnancy in women with thoracic aortic disease. Results Thoracic aortic disease was reported in 189 women (3.3%). Half of them were patients with Marfan syndrome (MFS), 26% had a BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos syndrome and 11% had no underlying genetic defect or associated congenital heart defect. Aortic dilatation was reported in 58% of patients and 6% had a history of aortic dissection. Four patients, of whom three were patients with MFS, had an acute aortic dissection (three type A and one type B aortic dissection) without maternal or fetal mortality. No complications occurred in women with a history of aortic dissection. There was no significant difference in median fetal birth weight if treated with a beta-blocker or not (2960 g (2358-3390 g) vs 3270 g (2750-3570 g), p value 0.25). Conclusion This ancillary analysis provides the largest prospective data review on pregnancy risk for patients with thoracic aortic disease. Overall pregnancy outcomes in women with thoracic aortic disease followed according to current guidelines are good.

    Original languageEnglish (US)
    Pages (from-to)1704-1709
    Number of pages6
    Issue number21
    StatePublished - Nov 1 2021


    • Marfan and associated disorders
    • aortic and arterial disease
    • aortic aneurysm
    • bicuspid aortic valve
    • pregnancy

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine


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