Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review

Stefano Palomba, Susanna Santagni, Karen Gibbins, Giovanni Battista La Sala, Robert M. Silver

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

In the literature, there is growing evidence that assisted reproductive techniques increase the risk of pregnancy complications in subfertile couples. Moreover, many concomitant preconception risk factors for subfertility are frequently present in the same subject and increase the risk of pregnancy complications. This review aimed to summarize in a systematic fashion the best current evidence regarding the effects of preconception maternal factors on maternal and neonatal outcomes. A literature search up to March 2016 was performed in IBSS, SocINDEX, Institute for Scientific Information, PubMed, Web of Science and Google Scholar. An evidence-based hierarchy was used to determine which articles to include and analyse. Available data show that the risk of pregnancy complications in spontaneous and assisted conceptions is likely multifactorial, and the magnitude of this risk is probably very different according specific subgroups of patients. Notwithstanding the only moderate level and quality of the available evidence, available data suggest that the presence and the treatment of specific preconception cofactors of subfertility should be always taken into account both in clinical practice and for scientific purposes.

Original languageEnglish (US)
Pages (from-to)612-628
Number of pages17
JournalReproductive BioMedicine Online
Volume33
Issue number5
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Fingerprint

Pregnancy Complications
Infertility
Mothers
Assisted Reproductive Techniques
PubMed
Therapeutics

Keywords

  • complications
  • infertility
  • obstetric
  • pregnancy
  • subfertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology

Cite this

Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review. / Palomba, Stefano; Santagni, Susanna; Gibbins, Karen; La Sala, Giovanni Battista; Silver, Robert M.

In: Reproductive BioMedicine Online, Vol. 33, No. 5, 01.11.2016, p. 612-628.

Research output: Contribution to journalReview article

Palomba, Stefano ; Santagni, Susanna ; Gibbins, Karen ; La Sala, Giovanni Battista ; Silver, Robert M. / Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review. In: Reproductive BioMedicine Online. 2016 ; Vol. 33, No. 5. pp. 612-628.
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