TY - JOUR
T1 - Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review
AU - Palomba, Stefano
AU - Santagni, Susanna
AU - Gibbins, Karen
AU - La Sala, Giovanni Battista
AU - Silver, Robert M.
N1 - Publisher Copyright:
© 2016 Reproductive Healthcare Ltd.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - In the literature, there is growing evidence that assisted reproductive techniques increase the risk of pregnancy complications in subfertile couples. Moreover, many concomitant preconception risk factors for subfertility are frequently present in the same subject and increase the risk of pregnancy complications. This review aimed to summarize in a systematic fashion the best current evidence regarding the effects of preconception maternal factors on maternal and neonatal outcomes. A literature search up to March 2016 was performed in IBSS, SocINDEX, Institute for Scientific Information, PubMed, Web of Science and Google Scholar. An evidence-based hierarchy was used to determine which articles to include and analyse. Available data show that the risk of pregnancy complications in spontaneous and assisted conceptions is likely multifactorial, and the magnitude of this risk is probably very different according specific subgroups of patients. Notwithstanding the only moderate level and quality of the available evidence, available data suggest that the presence and the treatment of specific preconception cofactors of subfertility should be always taken into account both in clinical practice and for scientific purposes.
AB - In the literature, there is growing evidence that assisted reproductive techniques increase the risk of pregnancy complications in subfertile couples. Moreover, many concomitant preconception risk factors for subfertility are frequently present in the same subject and increase the risk of pregnancy complications. This review aimed to summarize in a systematic fashion the best current evidence regarding the effects of preconception maternal factors on maternal and neonatal outcomes. A literature search up to March 2016 was performed in IBSS, SocINDEX, Institute for Scientific Information, PubMed, Web of Science and Google Scholar. An evidence-based hierarchy was used to determine which articles to include and analyse. Available data show that the risk of pregnancy complications in spontaneous and assisted conceptions is likely multifactorial, and the magnitude of this risk is probably very different according specific subgroups of patients. Notwithstanding the only moderate level and quality of the available evidence, available data suggest that the presence and the treatment of specific preconception cofactors of subfertility should be always taken into account both in clinical practice and for scientific purposes.
KW - complications
KW - infertility
KW - obstetric
KW - pregnancy
KW - subfertility
UR - http://www.scopus.com/inward/record.url?scp=84994121824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994121824&partnerID=8YFLogxK
U2 - 10.1016/j.rbmo.2016.08.007
DO - 10.1016/j.rbmo.2016.08.007
M3 - Review article
C2 - 27591135
AN - SCOPUS:84994121824
SN - 1472-6483
VL - 33
SP - 612
EP - 628
JO - Reproductive biomedicine online
JF - Reproductive biomedicine online
IS - 5
ER -