Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin

Barbara H. Iglewski, Marvin B. Rittenberg, Wallace J. Iglewski

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Protein synthesis in Rous sarcoma virus-transformed cultured chick embryo cells is shown to be more sensitive to diphtheria toxin than protein synthesis in normal chick embryo fibroblasts. Similarly, cells from viral-induced sarcomas are more sensitive to diphtheria toxin than cells from normal tissues of the same chicken. Diphtheria toxin inhibits the growth of virus-transformed chick cells in culture at a concentration that has no effect on control cells.

Original languageEnglish (US)
Pages (from-to)272-275
Number of pages4
JournalVirology
Volume65
Issue number1
DOIs
StatePublished - May 1975

ASJC Scopus subject areas

  • Virology

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