TY - JOUR
T1 - Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin
AU - Iglewski, Barbara H.
AU - Rittenberg, Marvin B.
AU - Iglewski, Wallace J.
N1 - Funding Information:
This work was supported by PHS grants, No. IA111137C, A12355,a nd GRS 5FOlRR05412;P hi Beta Psi Sorority; the Medical Research Foundation of Oregon;a nd the American Cancer Society of Oregon.
PY - 1975/5
Y1 - 1975/5
N2 - Protein synthesis in Rous sarcoma virus-transformed cultured chick embryo cells is shown to be more sensitive to diphtheria toxin than protein synthesis in normal chick embryo fibroblasts. Similarly, cells from viral-induced sarcomas are more sensitive to diphtheria toxin than cells from normal tissues of the same chicken. Diphtheria toxin inhibits the growth of virus-transformed chick cells in culture at a concentration that has no effect on control cells.
AB - Protein synthesis in Rous sarcoma virus-transformed cultured chick embryo cells is shown to be more sensitive to diphtheria toxin than protein synthesis in normal chick embryo fibroblasts. Similarly, cells from viral-induced sarcomas are more sensitive to diphtheria toxin than cells from normal tissues of the same chicken. Diphtheria toxin inhibits the growth of virus-transformed chick cells in culture at a concentration that has no effect on control cells.
UR - http://www.scopus.com/inward/record.url?scp=0016832212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016832212&partnerID=8YFLogxK
U2 - 10.1016/0042-6822(75)90029-X
DO - 10.1016/0042-6822(75)90029-X
M3 - Article
C2 - 167518
AN - SCOPUS:0016832212
SN - 0042-6822
VL - 65
SP - 272
EP - 275
JO - Virology
JF - Virology
IS - 1
ER -