Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin

Barbara H. Iglewski, Marvin Rittenberg, Wallace J. Iglewski

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Protein synthesis in Rous sarcoma virus-transformed cultured chick embryo cells is shown to be more sensitive to diphtheria toxin than protein synthesis in normal chick embryo fibroblasts. Similarly, cells from viral-induced sarcomas are more sensitive to diphtheria toxin than cells from normal tissues of the same chicken. Diphtheria toxin inhibits the growth of virus-transformed chick cells in culture at a concentration that has no effect on control cells.

Original languageEnglish (US)
Pages (from-to)272-275
Number of pages4
JournalVirology
Volume65
Issue number1
DOIs
StatePublished - 1975

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Diphtheria Toxin
Rous sarcoma virus
Chick Embryo
Growth
Proteins
Sarcoma
Chickens
Cell Culture Techniques
Fibroblasts
Viruses

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin. / Iglewski, Barbara H.; Rittenberg, Marvin; Iglewski, Wallace J.

In: Virology, Vol. 65, No. 1, 1975, p. 272-275.

Research output: Contribution to journalArticle

Iglewski, Barbara H. ; Rittenberg, Marvin ; Iglewski, Wallace J. / Preferential inhibition of growth and protein synthesis in Rous sarcoma virus transformed cells by diphtheria toxin. In: Virology. 1975 ; Vol. 65, No. 1. pp. 272-275.
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