Preeclampsia

Syndrome or Disease?

Leslie Myatt, James M. Roberts

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The focus on disease mechanisms underlying the hypertension and proteinuria defining preeclampsia has increased knowledge of the pathophysiology yet we lack both therapy and predictors. We propose this is in part due to the fact that diagnostic findings identify a “preeclampsia syndrome” but do not necessarily indicate the most important pathophysiology nor if organs are involved as cause or consequence. The increased risk for later life cardiovascular disease in women who develop preeclampsia suggests the stress test of pregnancy exposes pre-existing subclinical vascular disease. The dogma that inadequate trophoblast invasion and ischemia/reperfusion injury to the placenta is “the” cause of preeclampsia is more relevant to early onset preeclampsia (

Original languageEnglish (US)
Article number83
JournalCurrent Hypertension Reports
Volume17
Issue number11
DOIs
StatePublished - Nov 22 2015
Externally publishedYes

Fingerprint

Pre-Eclampsia
Trophoblasts
Reperfusion Injury
Exercise Test
Vascular Diseases
Proteinuria
Placenta
Cardiovascular Diseases
Hypertension
Pregnancy
Therapeutics

Keywords

  • Angiogenic factors
  • Biomarkers
  • Cardiovascular disease
  • Placenta
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Preeclampsia : Syndrome or Disease? / Myatt, Leslie; Roberts, James M.

In: Current Hypertension Reports, Vol. 17, No. 11, 83, 22.11.2015.

Research output: Contribution to journalArticle

Myatt, Leslie ; Roberts, James M. / Preeclampsia : Syndrome or Disease?. In: Current Hypertension Reports. 2015 ; Vol. 17, No. 11.
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