Predominant involvement of mu- rather than delta- or kappa-opiate receptors in LH secretion

D. G. Pfeiffer, A. Pfeiffer, Y. Shimohigashi, G. R. Merriam, D. L. Loriaux

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin release. Three highly selective opioid ligands, DAGO, MRZ and DTE12 (a dimeric tetrapeptide enkephalin), were injected intraventricularly into chronically ovariectomized rats. Injection of the mu-agonist at doses of 1 and 10 nmol produced a significant suppression of LH secretion, while the delta- and kappa-agonists had no significant effect. Thus, the mu-receptor seems to be the primary opiate receptor involved in the regulation of LH secretion. None of the opiate agonists employed had an effect on FSH secretion.

Original languageEnglish (US)
Pages (from-to)647-649
Number of pages3
JournalPeptides
Volume4
Issue number5
DOIs
StatePublished - Jan 1 1983

Keywords

  • Gonadotropins
  • Naloxone
  • Opiate receptor subtypes
  • Opioid peptides
  • Ovariectomized rats

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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