Predominance of CD4+ T Cells in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma and Identification of a Subset of Patients With Peripheral B-Cell Lymphopenia

Christian Kunder, Michael Cascio, Anthony Bakke, Girish Venkataraman, Dennis P. O'Malley, Robert S. Ohgami

Research output: Contribution to journalArticle

4 Scopus citations


Objectives: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a morphologic variant of large B-cell lymphoma whose flow cytometry findings are not well characterized.

Methods: Nineteen cases with flow cytometric immunophenotyping were identified from the case records of four institutions between 2001 and 2016.

Results: In most cases, neoplastic B cells were not detected by flow cytometry. Overall, cases showed a predominance of CD4+ T cells, which in some cases was marked. Significant coexpression of CD57 was seen on CD4+ T cells where this marker was analyzed, which correlated with PD-1 expression. Two cases also showed a profound systemic B-cell lymphopenia, which was associated in one case with hypogammaglobulinemia.

Conclusions: Overall, our work challenges previous findings that cases of THRLBCL are rich in CD8+ T cells and highlights parallels between THRLBCL and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Also, an association of THRLBCL with systemic B-cell lymphopenia has not been previously reported but may represent an underrecognized manifestation.

Original languageEnglish (US)
Pages (from-to)596-603
Number of pages8
JournalAmerican Journal of Clinical Pathology
Issue number6
StatePublished - Jun 1 2017
Externally publishedYes



  • Flow cytometry
  • PD-1
  • T-cell histiocyte-rich large B-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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