Predictors of the progression of dementia severity in Brazilian patients with Alzheimer's disease and vascular dementia

Márcia L. Chaves, Ana L. Camozzato, Cristiano Khler, Jeffrey Kaye

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Introduction. This study evaluates the progression of dementia and identifies prognostic risk factors for dementia. Methods. A group of 80 Brazilian community residents with dementia (34 with Alzheimer's disease and 46 with vascular dementia) was assessed over the course of 2 years. Data were analyzed with Cox regression survival analysis. Results. The data showed that education predicted cognitive decline (HR=1.2; P<.05) when analyzed without controlling for vascular risk factors. After the inclusion of vascular risk factors, education (HR=1.32; P<.05) and hypertension were predictive for cognitive decline (HR=38; P<.05), and Alzheimer's disease diagnosis was borderline predictive (P=.055). Conclusion. Vascular risk factors interacted with the diagnosis of vascular dementia. Education was a strong predictor of decline.

Original languageEnglish (US)
Article number673581
JournalInternational Journal of Alzheimer's Disease
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Aging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience

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