Predictors of olfactory dysfunction in patients with chronic rhinosinusitis

Jamie R. Litvack, Karen Fong, Jess Mace, Kenneth E. James, Timothy Smith

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objectives: To measure the prevalence of and identify clinical characteristics associated with poor olfactory function in a large cohort of patients with chronic rhinosinusitis (CRS). Study Design: Multi-institutional, cross sectional analysis. Methods: An objective measure of olfactory dysfunction, the Smell Identification Test, demographic data, clinical factors, and comorbidity data were collected from a cohort of 367 patients who presented with CRS at three tertiary care centers. Data were analyzed using univariate and multivariate analyses. Results: Sixty-four percent of men and women aged 18 to 64 had olfactory dysfunction whereas 95% of patients older than or equal to 65 years had olfactory dysfunction (P <.001); no significant difference was noted by gender. By multivariate logistic regression analysis, patients with nasal polyposis [Odds ratio (OR) 2.4, 95% confidence interval (CI) 1.3-4.2, P=.003] and patients older than or equal to 65 years (OR 10.0, 95% CI 2.3-43.7, P=.002) were at increased risk of hyposmia. Patients with nasal polyposis (OR 13.2, 95% CI 5.7-30.7, P <.001), asthma (OR 4.2, 95% CI 1.8-9.8, P=.001), older than or equal to 65 years (OR 15.6, 95% CI 2.3-104.9, P=.005), and smokers (OR 7.6, 95% CI 1.8-31.6, P=.005) were at increased risk of anosmia. Conclusions: Poor olfactory function is common in patients with CRS. Age, nasal polyposis, smoking, and asthma were significantly associated with olfactory dysfunction in patients with CRS. Neither prior endoscopic sinus surgery nor a history of allergic rhinitis was associated with olfactory dysfunction. Septal deviation and inferior turbinate hypertrophy were associated with normal olfactory function.

Original languageEnglish (US)
Pages (from-to)2225-2230
Number of pages6
JournalLaryngoscope
Volume118
Issue number12
DOIs
StatePublished - Dec 2008

Fingerprint

Odds Ratio
Confidence Intervals
Nose
Asthma
Olfaction Disorders
Turbinates
Smell
Tertiary Care Centers
Hypertrophy
Comorbidity
Multivariate Analysis
Cross-Sectional Studies
Logistic Models
Smoking
Regression Analysis
Demography

Keywords

  • Anosmia
  • Chronic rhinosinusitis
  • Hyposmia
  • Olfactory dysfunction
  • Predictors

ASJC Scopus subject areas

  • Medicine(all)
  • Otorhinolaryngology

Cite this

Predictors of olfactory dysfunction in patients with chronic rhinosinusitis. / Litvack, Jamie R.; Fong, Karen; Mace, Jess; James, Kenneth E.; Smith, Timothy.

In: Laryngoscope, Vol. 118, No. 12, 12.2008, p. 2225-2230.

Research output: Contribution to journalArticle

Litvack, Jamie R. ; Fong, Karen ; Mace, Jess ; James, Kenneth E. ; Smith, Timothy. / Predictors of olfactory dysfunction in patients with chronic rhinosinusitis. In: Laryngoscope. 2008 ; Vol. 118, No. 12. pp. 2225-2230.
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abstract = "Objectives: To measure the prevalence of and identify clinical characteristics associated with poor olfactory function in a large cohort of patients with chronic rhinosinusitis (CRS). Study Design: Multi-institutional, cross sectional analysis. Methods: An objective measure of olfactory dysfunction, the Smell Identification Test, demographic data, clinical factors, and comorbidity data were collected from a cohort of 367 patients who presented with CRS at three tertiary care centers. Data were analyzed using univariate and multivariate analyses. Results: Sixty-four percent of men and women aged 18 to 64 had olfactory dysfunction whereas 95{\%} of patients older than or equal to 65 years had olfactory dysfunction (P <.001); no significant difference was noted by gender. By multivariate logistic regression analysis, patients with nasal polyposis [Odds ratio (OR) 2.4, 95{\%} confidence interval (CI) 1.3-4.2, P=.003] and patients older than or equal to 65 years (OR 10.0, 95{\%} CI 2.3-43.7, P=.002) were at increased risk of hyposmia. Patients with nasal polyposis (OR 13.2, 95{\%} CI 5.7-30.7, P <.001), asthma (OR 4.2, 95{\%} CI 1.8-9.8, P=.001), older than or equal to 65 years (OR 15.6, 95{\%} CI 2.3-104.9, P=.005), and smokers (OR 7.6, 95{\%} CI 1.8-31.6, P=.005) were at increased risk of anosmia. Conclusions: Poor olfactory function is common in patients with CRS. Age, nasal polyposis, smoking, and asthma were significantly associated with olfactory dysfunction in patients with CRS. Neither prior endoscopic sinus surgery nor a history of allergic rhinitis was associated with olfactory dysfunction. Septal deviation and inferior turbinate hypertrophy were associated with normal olfactory function.",
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