Predictors of malignancy development in patients with chronic pruritus

Nicole Fett, Kevin Haynes, Kathleen Joy Propert, David J. Margolis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Patients with pruritus have been shown to have an increased incidence of certain subtypes of malignancy. Objective: To assess predictors of malignancy in patients with chronic pruritus without prior dermatologic diagnoses. Methods: Case-control study of 398 patients with chronic pruritus who developed a malignancy were compared with 8346 patients with chronic pruritus who did not develop a malignancy. Primary outcomes were odds of developing incident malignancy. Results: Age greater than 60 years (OR 4.04, 95% CI 3.08, 5.31), male sex (OR 1.39, 95% CI 1.13, 1.71) and liver disease (OR 2.37, 95% CI 1.00, 5.65) were predictors of malignancy development in patients with chronic pruritus and non-diseased skin. In an exploratory analysis with multiple imputation via chained equations, age greater than 60 years (OR 4.13, 95% CI 3.15, 5.42), male sex (OR 1.26, 95% CI 1.02, 1.55), and current or prior smoking (OR 2.02, 95% CI 1.42, 2.88) were predictors of malignancy development in patients with chronic pruritus and non-diseased skin. Limitations: Potential for misclassification and detection biases. Missing data. Conclusions and relevance: In patients with chronic pruritus without concomitant dermatologic diagnoses, older age, male sex, liver disease and tobacco abuse increase the odds of an underlying malignancy.

Original languageEnglish (US)
JournalJournal of Dermatological Science
DOIs
StateAccepted/In press - Nov 3 2015

Fingerprint

Pruritus
Liver
Skin
Tobacco
Neoplasms
Liver Diseases
Case-Control Studies
Smoking
Incidence

Keywords

  • Itch
  • Malignancy risk factors
  • Medical dermatology
  • Pruritus
  • Pruritus as a sign of systemic disease
  • Screening for malignancy

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Molecular Biology

Cite this

Predictors of malignancy development in patients with chronic pruritus. / Fett, Nicole; Haynes, Kevin; Propert, Kathleen Joy; Margolis, David J.

In: Journal of Dermatological Science, 03.11.2015.

Research output: Contribution to journalArticle

Fett, Nicole ; Haynes, Kevin ; Propert, Kathleen Joy ; Margolis, David J. / Predictors of malignancy development in patients with chronic pruritus. In: Journal of Dermatological Science. 2015.
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