Predictors of highly active antiretroviral therapy utilization for behaviorally HIV-1-infected youth

Impact of adult versus pediatric clinical care site

Allison L. Agwu, George K. Siberry, Jonathan Ellen, John A. Fleishman, Richard Rutstein, Aditya H. Gaur, Philip (Todd) Korthuis, Robert Warford, Stephen A. Spector, Kelly A. Gebo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: We evaluated highly active antiretroviral therapy (HAART) utilization in youth infected with HIV through risk behaviors who met treatment criteria for HAART. We assessed the impact of receiving care at an adult or pediatric HIV clinical site on initiation and discontinuation of the first HAART regimen in behaviorally infected youth (BIY). Methods: This was a retrospective analysis of treatment-naive BIY, aged 12-24 years, who enrolled in the HIV Research Network between 2002 and 2008 and who met criteria for HAART. The outcomes were time from meeting criteria to initiation of HAART and time to discontinuation of the first HAART regimen. Analyses were conducted using Cox proportional hazards regression. Results: Of 287 treatment-eligible youth, 198 (69%) received HAART; of these 198 youth, 58 (29.3%) subsequently discontinued HAART. In multivariable analyses, there was no significant difference in the time between meeting treatment criteria and initiating HAART for BIY followed at adult or pediatric HIV clinical sites. However, BIY followed at adult sites discontinued HAART sooner than BIY followed at pediatric HIV clinical sites (adjusted hazard ratio [AHR]: 3.19 [1.26-8.06]). Conclusions: Two-thirds of treatment-eligible BIY in the HIV Research Network cohort initiated HAART; however, one-third who initiated HAART discontinued it during the study period. Identifying factors associated with earlier HAART initiation and sustainability can inform interventions to enhance HAART utilization among treatment-eligible youth. The finding of earlier HAART discontinuation for youth at adult care sites deserves further study.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalJournal of Adolescent Health
Volume50
Issue number5
DOIs
StatePublished - May 2012

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Highly Active Antiretroviral Therapy
HIV-1
Pediatrics
HIV
Secondary Prevention
Therapeutics
Risk-Taking
Research

Keywords

  • Adolescents
  • Clinical site
  • Disparities
  • Highly active antiretroviral therapy (HAART)
  • HIV Research Network
  • Utilization
  • Youth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health

Cite this

Predictors of highly active antiretroviral therapy utilization for behaviorally HIV-1-infected youth : Impact of adult versus pediatric clinical care site. / Agwu, Allison L.; Siberry, George K.; Ellen, Jonathan; Fleishman, John A.; Rutstein, Richard; Gaur, Aditya H.; Korthuis, Philip (Todd); Warford, Robert; Spector, Stephen A.; Gebo, Kelly A.

In: Journal of Adolescent Health, Vol. 50, No. 5, 05.2012, p. 471-477.

Research output: Contribution to journalArticle

Agwu, Allison L. ; Siberry, George K. ; Ellen, Jonathan ; Fleishman, John A. ; Rutstein, Richard ; Gaur, Aditya H. ; Korthuis, Philip (Todd) ; Warford, Robert ; Spector, Stephen A. ; Gebo, Kelly A. / Predictors of highly active antiretroviral therapy utilization for behaviorally HIV-1-infected youth : Impact of adult versus pediatric clinical care site. In: Journal of Adolescent Health. 2012 ; Vol. 50, No. 5. pp. 471-477.
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abstract = "Objectives: We evaluated highly active antiretroviral therapy (HAART) utilization in youth infected with HIV through risk behaviors who met treatment criteria for HAART. We assessed the impact of receiving care at an adult or pediatric HIV clinical site on initiation and discontinuation of the first HAART regimen in behaviorally infected youth (BIY). Methods: This was a retrospective analysis of treatment-naive BIY, aged 12-24 years, who enrolled in the HIV Research Network between 2002 and 2008 and who met criteria for HAART. The outcomes were time from meeting criteria to initiation of HAART and time to discontinuation of the first HAART regimen. Analyses were conducted using Cox proportional hazards regression. Results: Of 287 treatment-eligible youth, 198 (69{\%}) received HAART; of these 198 youth, 58 (29.3{\%}) subsequently discontinued HAART. In multivariable analyses, there was no significant difference in the time between meeting treatment criteria and initiating HAART for BIY followed at adult or pediatric HIV clinical sites. However, BIY followed at adult sites discontinued HAART sooner than BIY followed at pediatric HIV clinical sites (adjusted hazard ratio [AHR]: 3.19 [1.26-8.06]). Conclusions: Two-thirds of treatment-eligible BIY in the HIV Research Network cohort initiated HAART; however, one-third who initiated HAART discontinued it during the study period. Identifying factors associated with earlier HAART initiation and sustainability can inform interventions to enhance HAART utilization among treatment-eligible youth. The finding of earlier HAART discontinuation for youth at adult care sites deserves further study.",
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AU - Fleishman, John A.

AU - Rutstein, Richard

AU - Gaur, Aditya H.

AU - Korthuis, Philip (Todd)

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