Predictors of Early Hospitalization After Deceased Donor Liver Transplantation

Jessica Yu, Amy Hosmer, Tamara Parks, Christopher J. Sonnenday, Pratima Sharma

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Abstract: Hospitalizations after solid organ transplantation may affect patient outcomes. Identification of the factors attributed to them may decrease hospitalization rates, reduce overall cost, and improve post-transplant outcomes. We examined the risk factors for early hospitalization within 30 and 90 days after liver transplantation (LT). Methods: Data on all deceased donor LT recipients (age ≥18 years) transplanted between 2/28/2002–2/27/2007 and discharged alive from the index hospitalization within 30 days of LT were collected (N = 267). Patients were followed up until December 31, 2013. Logistic regression was used to identify the predictors of 30-day hospitalization, and linear regression was used to identify the factors associated with number of days hospitalized during 30- and 90-day hospitalization after LT. Renal risk index (RRI), a recently developed and validated risk score that accurately predicts the post-LT ESRD based upon recipient factors at LT, was computed using RRI calculator (http://rri.med.umich.edu). Results: One-third and more than half of the patients had at least one 30- and 90-day hospitalization, respectively. RRI decile (OR 1.12, P = 0.02) and serum sodium at LT (OR 0.90, P < 0.001) were independently associated with 30-day hospitalization after adjusting for MELD score. Serum creatinine at LT (β = 4.34, P = 0.001) and pre-LT admission days (β = 0.15, P = 0.027) affected the number of days hospitalized for 90-day hospitalization. RRI was also an independent predictor of post-LT mortality. Conclusion: Early hospitalizations within 30 and 90 days after deceased donor LT are common. While all post-LT hospitalization cannot be prevented, efforts should be directed toward risk-based post-discharge care, and coordination of effective transitional care through ambulatory clinics. Implementation of such processes may attenuate early post-LT hospitalization and resource utilization and improve quality.

Original languageEnglish (US)
Pages (from-to)3242-3247
Number of pages6
JournalDigestive diseases and sciences
Volume60
Issue number11
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Keywords

  • Creatinine
  • Hospitalization
  • Liver transplantation
  • MELD
  • Renal risk index (RRI)

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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