Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease

Laura M. Drudi, Melinda S. Schaller, Jade Hiramoto, Warren Gasper, William Harris, Nancy K. Hills, S. Marlene Grenon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background The omega-3 index represents the red blood cell (RBC) content of two major long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid, and docosahexaenoic acid. We sought to determine factors associated with a favorable response to fish oil treatment and to characterize changes in RBC PUFAs associated with fish oil supplementation. Methods This study was a secondary analysis of the OMEGA-PAD I trial, a randomized, double-blinded, placebo-controlled trial investigating short-duration, high-dose n-3 PUFA oral supplementation on endothelial function and inflammation in subjects with peripheral arterial disease. Patients with mild to severe claudication received either 4.4 g of fish oil providing 2.6 g of eicosapentaenoic acid and 1.8 g of docosahexaenoic acid daily (n = 40) or placebo capsules (n = 40) for 1 mo. The RBC fatty acid content was measured by gas chromatography and expressed as a percent of total fatty acids. The change in omega-3 index was calculated as the difference between pre- and post-supplementation in the fish oil and placebo groups. Univariate analysis identified predictors of change in omega-3 index, with these variables included in our multivariable model. Results In the fish oil group, there was an increase in the omega-3 index (5.1± 1.3% to 9.0± 1.8%; P < 0.0001), whereas there was no change in the control group. Factors associated with a favorable response (i.e., greater than the median change of 4.06%) included a lower body mass index and higher concentrations of low-density lipoproteins. Other demographic and/or lifestyle factors such as age, race, or smoking status were unrelated to the response. Oral n-3 PUFA supplementation also decreased the n-6 PUFA content in RBCs. Conclusions Short-term, high-dose n-3 PUFA supplementation increases the omega-3 index to a greater extent in patients with a lower body mass index and higher total and low-density lipoprotein cholesterol levels.

Original languageEnglish (US)
Pages (from-to)124-131
Number of pages8
JournalJournal of Surgical Research
Volume210
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

Fish Oils
Peripheral Arterial Disease
Omega-3 Fatty Acids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Erythrocytes
Placebos
Unsaturated Fatty Acids
Body Mass Index
Fatty Acids
LDL Lipoproteins
Gas Chromatography
LDL Cholesterol
Capsules
Life Style
Smoking
Demography
Inflammation
Control Groups

Keywords

  • Fish oil
  • n-3 polyunsaturated fatty acids
  • Omega-3 index
  • Peripheral artery disease

ASJC Scopus subject areas

  • Surgery

Cite this

Drudi, L. M., Schaller, M. S., Hiramoto, J., Gasper, W., Harris, W., Hills, N. K., & Grenon, S. M. (2017). Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease. Journal of Surgical Research, 210, 124-131. https://doi.org/10.1016/j.jss.2016.11.011

Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease. / Drudi, Laura M.; Schaller, Melinda S.; Hiramoto, Jade; Gasper, Warren; Harris, William; Hills, Nancy K.; Grenon, S. Marlene.

In: Journal of Surgical Research, Vol. 210, 01.04.2017, p. 124-131.

Research output: Contribution to journalArticle

Drudi, LM, Schaller, MS, Hiramoto, J, Gasper, W, Harris, W, Hills, NK & Grenon, SM 2017, 'Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease', Journal of Surgical Research, vol. 210, pp. 124-131. https://doi.org/10.1016/j.jss.2016.11.011
Drudi, Laura M. ; Schaller, Melinda S. ; Hiramoto, Jade ; Gasper, Warren ; Harris, William ; Hills, Nancy K. ; Grenon, S. Marlene. / Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease. In: Journal of Surgical Research. 2017 ; Vol. 210. pp. 124-131.
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abstract = "Background The omega-3 index represents the red blood cell (RBC) content of two major long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid, and docosahexaenoic acid. We sought to determine factors associated with a favorable response to fish oil treatment and to characterize changes in RBC PUFAs associated with fish oil supplementation. Methods This study was a secondary analysis of the OMEGA-PAD I trial, a randomized, double-blinded, placebo-controlled trial investigating short-duration, high-dose n-3 PUFA oral supplementation on endothelial function and inflammation in subjects with peripheral arterial disease. Patients with mild to severe claudication received either 4.4 g of fish oil providing 2.6 g of eicosapentaenoic acid and 1.8 g of docosahexaenoic acid daily (n = 40) or placebo capsules (n = 40) for 1 mo. The RBC fatty acid content was measured by gas chromatography and expressed as a percent of total fatty acids. The change in omega-3 index was calculated as the difference between pre- and post-supplementation in the fish oil and placebo groups. Univariate analysis identified predictors of change in omega-3 index, with these variables included in our multivariable model. Results In the fish oil group, there was an increase in the omega-3 index (5.1± 1.3{\%} to 9.0± 1.8{\%}; P < 0.0001), whereas there was no change in the control group. Factors associated with a favorable response (i.e., greater than the median change of 4.06{\%}) included a lower body mass index and higher concentrations of low-density lipoproteins. Other demographic and/or lifestyle factors such as age, race, or smoking status were unrelated to the response. Oral n-3 PUFA supplementation also decreased the n-6 PUFA content in RBCs. Conclusions Short-term, high-dose n-3 PUFA supplementation increases the omega-3 index to a greater extent in patients with a lower body mass index and higher total and low-density lipoprotein cholesterol levels.",
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AU - Harris, William

AU - Hills, Nancy K.

AU - Grenon, S. Marlene

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N2 - Background The omega-3 index represents the red blood cell (RBC) content of two major long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid, and docosahexaenoic acid. We sought to determine factors associated with a favorable response to fish oil treatment and to characterize changes in RBC PUFAs associated with fish oil supplementation. Methods This study was a secondary analysis of the OMEGA-PAD I trial, a randomized, double-blinded, placebo-controlled trial investigating short-duration, high-dose n-3 PUFA oral supplementation on endothelial function and inflammation in subjects with peripheral arterial disease. Patients with mild to severe claudication received either 4.4 g of fish oil providing 2.6 g of eicosapentaenoic acid and 1.8 g of docosahexaenoic acid daily (n = 40) or placebo capsules (n = 40) for 1 mo. The RBC fatty acid content was measured by gas chromatography and expressed as a percent of total fatty acids. The change in omega-3 index was calculated as the difference between pre- and post-supplementation in the fish oil and placebo groups. Univariate analysis identified predictors of change in omega-3 index, with these variables included in our multivariable model. Results In the fish oil group, there was an increase in the omega-3 index (5.1± 1.3% to 9.0± 1.8%; P < 0.0001), whereas there was no change in the control group. Factors associated with a favorable response (i.e., greater than the median change of 4.06%) included a lower body mass index and higher concentrations of low-density lipoproteins. Other demographic and/or lifestyle factors such as age, race, or smoking status were unrelated to the response. Oral n-3 PUFA supplementation also decreased the n-6 PUFA content in RBCs. Conclusions Short-term, high-dose n-3 PUFA supplementation increases the omega-3 index to a greater extent in patients with a lower body mass index and higher total and low-density lipoprotein cholesterol levels.

AB - Background The omega-3 index represents the red blood cell (RBC) content of two major long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid, and docosahexaenoic acid. We sought to determine factors associated with a favorable response to fish oil treatment and to characterize changes in RBC PUFAs associated with fish oil supplementation. Methods This study was a secondary analysis of the OMEGA-PAD I trial, a randomized, double-blinded, placebo-controlled trial investigating short-duration, high-dose n-3 PUFA oral supplementation on endothelial function and inflammation in subjects with peripheral arterial disease. Patients with mild to severe claudication received either 4.4 g of fish oil providing 2.6 g of eicosapentaenoic acid and 1.8 g of docosahexaenoic acid daily (n = 40) or placebo capsules (n = 40) for 1 mo. The RBC fatty acid content was measured by gas chromatography and expressed as a percent of total fatty acids. The change in omega-3 index was calculated as the difference between pre- and post-supplementation in the fish oil and placebo groups. Univariate analysis identified predictors of change in omega-3 index, with these variables included in our multivariable model. Results In the fish oil group, there was an increase in the omega-3 index (5.1± 1.3% to 9.0± 1.8%; P < 0.0001), whereas there was no change in the control group. Factors associated with a favorable response (i.e., greater than the median change of 4.06%) included a lower body mass index and higher concentrations of low-density lipoproteins. Other demographic and/or lifestyle factors such as age, race, or smoking status were unrelated to the response. Oral n-3 PUFA supplementation also decreased the n-6 PUFA content in RBCs. Conclusions Short-term, high-dose n-3 PUFA supplementation increases the omega-3 index to a greater extent in patients with a lower body mass index and higher total and low-density lipoprotein cholesterol levels.

KW - Fish oil

KW - n-3 polyunsaturated fatty acids

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KW - Peripheral artery disease

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