Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. Methods The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer. Results The subjects’ mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing. Conclusions NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.

Original languageEnglish (US)
Pages (from-to)478-483
Number of pages6
JournalJournal of Vascular Surgery
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2017

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Wound Healing
Neutrophils
Amputation
Ulcer
Lymphocytes
Diabetic Foot
Wounds and Injuries
Wound Infection
Multivariate Analysis
Biomarkers
Odds Ratio
Demography
Inflammation

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing. / Vatankhah, Nasibeh; Jahangiri, Younes; Landry, Gregory; Mclafferty, Robert; Alkayed, Nabil; Moneta, Gregory (Greg); Azarbal, Amir.

In: Journal of Vascular Surgery, Vol. 65, No. 2, 01.02.2017, p. 478-483.

Research output: Contribution to journalArticle

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AU - Moneta, Gregory (Greg)

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AB - Objective The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. Methods The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer. Results The subjects’ mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing. Conclusions NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.

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