Predictive value of beat-to-beat qt variability index across the continuum of left ventricular dysfunction competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death

Larisa Tereshchenko, Iwona Cygankiewicz, Scott McNitt, Rafael Vazquez, Antoni Bayes-Genis, Lichy Han, Sanjoli Sur, Jean Philippe Couderc, Ronald D. Berger, Antoni Bayes De Luna, Wojciech Zareba

Research output: Contribution to journalArticle

41 Scopus citations


Background-The goal of the present study was to determine the predictive value of beat-to-beat QT variability in heart failure patients across the continuum of left ventricular dysfunction. Methods and Results-Beat-to-beat QT variability index (QTVI), log-transformed heart rate variance, normalized QT variance, and coherence between heart rate variability and QT variability have been measured at rest during sinus rhythm in 533 participants of the Muerte Subita en Insuficiencia Cardiaca heart failure study (mean age, 63.1±11.7; men, 70.6%; left ventricular ejection fraction >35% in 254 [48%]) and in 181 healthy participants from the Intercity Digital Electrocardiogram Alliance database. During a median of 3.7 years of follow-up, 116 patients died, 52 from sudden cardiac death (SCD). In multivariate competing risk analyses, the highest QTVI quartile was associated with cardiovascular death (subhazard ratio, 1.67 [95% CI, 1.14-2.47]; P=0.009) and, in particular, with non-SCD (subhazard ratio, 2.91 [1.69-5.01]; P

Original languageEnglish (US)
Pages (from-to)719-727
Number of pages9
JournalCirculation: Arrhythmia and Electrophysiology
Issue number4
Publication statusPublished - 2012
Externally publishedYes



  • ECG
  • Ejection fraction
  • Heart failure
  • QT variability
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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