Prediction of fetal drug concentrations

Debra Anderson, T. M. Phernetton, J. H.G. Rankin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Equations are derived for the fetal concentrations of a drug during and after the slow release of the drug into the maternal circulation. To solve these equations it is necessary to know the placental drug clearance, the clearance of the drug from the fetal circulation by the fetal tissues, the volume of distribution of the drug in the fetal compartment. With these values for acetylsalicylic acid (aspirin) it can be shown that the maximum fetal aspirin concentration will be much less than the maximum maternal concentration and that after the release of aspirin has stopped, some drug is trapped in the fetal circulation. Therefore, there will be a period of time when the fetal plasma aspirin concentration is greater than maternal plasma aspirin concentration.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume137
Issue number6
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Aspirin
Pharmaceutical Preparations
Mothers
Tissue Distribution
Fetus

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Prediction of fetal drug concentrations. / Anderson, Debra; Phernetton, T. M.; Rankin, J. H.G.

In: American Journal of Obstetrics and Gynecology, Vol. 137, No. 6, 1980, p. 735-738.

Research output: Contribution to journalArticle

Anderson, Debra ; Phernetton, T. M. ; Rankin, J. H.G. / Prediction of fetal drug concentrations. In: American Journal of Obstetrics and Gynecology. 1980 ; Vol. 137, No. 6. pp. 735-738.
@article{137f4d62e1fd465baefbdc14640bbc70,
title = "Prediction of fetal drug concentrations",
abstract = "Equations are derived for the fetal concentrations of a drug during and after the slow release of the drug into the maternal circulation. To solve these equations it is necessary to know the placental drug clearance, the clearance of the drug from the fetal circulation by the fetal tissues, the volume of distribution of the drug in the fetal compartment. With these values for acetylsalicylic acid (aspirin) it can be shown that the maximum fetal aspirin concentration will be much less than the maximum maternal concentration and that after the release of aspirin has stopped, some drug is trapped in the fetal circulation. Therefore, there will be a period of time when the fetal plasma aspirin concentration is greater than maternal plasma aspirin concentration.",
author = "Debra Anderson and Phernetton, {T. M.} and Rankin, {J. H.G.}",
year = "1980",
doi = "10.1016/S0002-9378(15)33251-8",
language = "English (US)",
volume = "137",
pages = "735--738",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Prediction of fetal drug concentrations

AU - Anderson, Debra

AU - Phernetton, T. M.

AU - Rankin, J. H.G.

PY - 1980

Y1 - 1980

N2 - Equations are derived for the fetal concentrations of a drug during and after the slow release of the drug into the maternal circulation. To solve these equations it is necessary to know the placental drug clearance, the clearance of the drug from the fetal circulation by the fetal tissues, the volume of distribution of the drug in the fetal compartment. With these values for acetylsalicylic acid (aspirin) it can be shown that the maximum fetal aspirin concentration will be much less than the maximum maternal concentration and that after the release of aspirin has stopped, some drug is trapped in the fetal circulation. Therefore, there will be a period of time when the fetal plasma aspirin concentration is greater than maternal plasma aspirin concentration.

AB - Equations are derived for the fetal concentrations of a drug during and after the slow release of the drug into the maternal circulation. To solve these equations it is necessary to know the placental drug clearance, the clearance of the drug from the fetal circulation by the fetal tissues, the volume of distribution of the drug in the fetal compartment. With these values for acetylsalicylic acid (aspirin) it can be shown that the maximum fetal aspirin concentration will be much less than the maximum maternal concentration and that after the release of aspirin has stopped, some drug is trapped in the fetal circulation. Therefore, there will be a period of time when the fetal plasma aspirin concentration is greater than maternal plasma aspirin concentration.

UR - http://www.scopus.com/inward/record.url?scp=0018946093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018946093&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(15)33251-8

DO - 10.1016/S0002-9378(15)33251-8

M3 - Article

C2 - 7395939

AN - SCOPUS:0018946093

VL - 137

SP - 735

EP - 738

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -