Prediction Models of Prevalent Radiographic Vertebral Fractures Among Older Women

John T. Schousboe, Harold R. Rosen, Tamara J. Vokes, Jane A. Cauley, Steven R. Cummings, Michael Nevitt, Dennis M. Black, Eric Orwoll, Deborah M. Kado, Kristine E. Ensrud

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It is unknown how well prediction models incorporating multiple risk factors identify women with radiographic prevalent vertebral fracture (PVFx) compared with simpler models and what their value might be in clinical practice to select older women for lateral spine imaging. We compared 4 regression models for predicting PVFx in women aged 68 y and older enrolled in the Study of Osteoporotic Fractures with a femoral neck T-score ≤ -1.0, using area under receiving operator characteristic curves (AUROC) and a net reclassification index. The AUROC for a model with age, femoral neck bone mineral density, historical height loss (HHL), prior nonspine fracture, body mass index, back pain, and grip strength was only minimally better than that of a more parsimonious model with age, femoral neck bone mineral density, and historical height loss (AUROC 0.689 vs 0.679, p values for difference in 5 bootstrapped samples

Original languageEnglish (US)
Pages (from-to)378-385
Number of pages8
JournalJournal of Clinical Densitometry
Volume17
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Femur Neck
Bone Density
Osteoporotic Fractures
Hand Strength
Back Pain
Spine
Body Mass Index

Keywords

  • Bone densitometry
  • Model discrimination
  • Prediction models
  • Prevalent vertebral fracture
  • Vertebral fracture assessment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Schousboe, J. T., Rosen, H. R., Vokes, T. J., Cauley, J. A., Cummings, S. R., Nevitt, M., ... Ensrud, K. E. (2014). Prediction Models of Prevalent Radiographic Vertebral Fractures Among Older Women. Journal of Clinical Densitometry, 17(3), 378-385. https://doi.org/10.1016/j.jocd.2013.09.021

Prediction Models of Prevalent Radiographic Vertebral Fractures Among Older Women. / Schousboe, John T.; Rosen, Harold R.; Vokes, Tamara J.; Cauley, Jane A.; Cummings, Steven R.; Nevitt, Michael; Black, Dennis M.; Orwoll, Eric; Kado, Deborah M.; Ensrud, Kristine E.

In: Journal of Clinical Densitometry, Vol. 17, No. 3, 2014, p. 378-385.

Research output: Contribution to journalArticle

Schousboe, JT, Rosen, HR, Vokes, TJ, Cauley, JA, Cummings, SR, Nevitt, M, Black, DM, Orwoll, E, Kado, DM & Ensrud, KE 2014, 'Prediction Models of Prevalent Radiographic Vertebral Fractures Among Older Women', Journal of Clinical Densitometry, vol. 17, no. 3, pp. 378-385. https://doi.org/10.1016/j.jocd.2013.09.021
Schousboe, John T. ; Rosen, Harold R. ; Vokes, Tamara J. ; Cauley, Jane A. ; Cummings, Steven R. ; Nevitt, Michael ; Black, Dennis M. ; Orwoll, Eric ; Kado, Deborah M. ; Ensrud, Kristine E. / Prediction Models of Prevalent Radiographic Vertebral Fractures Among Older Women. In: Journal of Clinical Densitometry. 2014 ; Vol. 17, No. 3. pp. 378-385.
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