Predicting fatal sepsis in bum patients

Christopher C. Baker, Carol L. Miller, Donald Trunkey

Research output: Contribution to journalArticle

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Abstract

The high morbidity after severe thermal insult is believed to be related partially to a resultant decrease in immunocompetence. We tested the ability of phytohemagglutinin (PHA) and Concanavalin (Con A) to stimulate lymphocyte transformation in 17 patients with moderate to severe thermal injury (>25% BSA). The patients acted as their own controls and the per cent change in their mitogen response was measured over time. Eight acutely burned patients who subsequently developed severe sepsis (Group I) had decreased ability (mean, 12% of normal) to proliferate in response to PHA, and six of these died of severe sepsis. The depressed response appeared 4 to 7 days postinjury and predated clinical evidence of sepsis by 2 to 4 days. Cells from four patients who had mild infectious complications (Group II) demonstrated greatly augmented mitogen responses (mean + 243%) approximately 7 to 10 days postinjury. Five bum patients whose clinical course was sepsis free (Group III) exhibited only minimal changes in their mitogen responses (mean +30%). Although the Con A responses of the patients’ cells corresponded less to their pathology, Group I patients whose cells exhibited depressed PHA responsiveness also had diminished Con A responses. Group II patients’ cells also showed increases in Con A-induced stimulation. Group HI patients, who had only slightly augmented PHA responses, had minimal decreases of the Con A-induced lymphocyte transformation. Many severely burned patients develop septicemia as a result of their large wound surfaces. The appearance of decreases in mitogen-induced proliferation, however, appears to characterize those patients who will be unable to handle the septic challenge.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume19
Issue number9
StatePublished - 1979
Externally publishedYes

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Sepsis
Phytohemagglutinins
Mitogens
Lymphocyte Activation
Hot Temperature
Immunocompetence
Wounds and Injuries
Pathology
Morbidity

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Predicting fatal sepsis in bum patients. / Baker, Christopher C.; Miller, Carol L.; Trunkey, Donald.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 19, No. 9, 1979, p. 641-648.

Research output: Contribution to journalArticle

Baker, Christopher C. ; Miller, Carol L. ; Trunkey, Donald. / Predicting fatal sepsis in bum patients. In: Journal of Trauma - Injury, Infection and Critical Care. 1979 ; Vol. 19, No. 9. pp. 641-648.
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