Precursors to rapid elevations in intracranial pressure

James McNames, Cristina Crespo, Mateo Aboy, Miles Ellenby, Susanna Lai, Robert Sclabassi, Brahm Goldstein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Intracranial pressure (ICP) monitoring and management have substantially improved the outcome of patients with traumatic brain injury (TBI). However, rapid elevations in ICP remain a significant problem as they may lead to secondary brain injury and worse outcome due to cerebral ischemia. Current therapy is targeted towards treating rapid ICP elevations after they occur. Ideally, anticipatory treatment to obviate any elevation in ICP could occur if reliable precursors to ICP elevation were determined. In this paper, we report evidence for a physiologic transition zone prior to rapid elevations in ICP. We found that in thirty-three episodes of ICP elevation recorded from eleven patients, there was a statistically consistent decrease in the cardiac component of the ICP signal and the coefficient of correlation between the ICP trend and the pulse amplitude. We conclude that specific ICP signal metrics may serve as precursors that characterize the transition zone prior to a rapid elevation and may enable prediction of these elevations up to thirty seconds ahead.

Original languageEnglish (US)
Title of host publicationAnnual Reports of the Research Reactor Institute, Kyoto University
Pages3977-3980
Number of pages4
Volume4
Publication statusPublished - 2001
Externally publishedYes
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: Oct 25 2001Oct 28 2001

Other

Other23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryTurkey
CityIstanbul
Period10/25/0110/28/01

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Keywords

  • Autoregulation
  • Cerebral perfussion pressure
  • Head injury
  • Intracranial hypertension
  • Intracranial pressure
  • Time series prediction
  • Traumatic brain injury

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Mechanical Engineering

Cite this

McNames, J., Crespo, C., Aboy, M., Ellenby, M., Lai, S., Sclabassi, R., & Goldstein, B. (2001). Precursors to rapid elevations in intracranial pressure. In Annual Reports of the Research Reactor Institute, Kyoto University (Vol. 4, pp. 3977-3980)