Precursors and Development of Geographic Atrophy with Autofluorescence Imaging: Age-Related Eye Disease Study 2 Report Number 18

Age-Related Eye Disease Study 2 Research Group

Research output: Contribution to journalArticle

Abstract

Purpose: To describe the sequence of events leading to development of geographic atrophy (GA) in age-related macular degeneration with fundus autofluorescence (FAF) imaging. Design: Post hoc analysis of FAF images from the Age-Related Eye Disease Study 2. Participants: Fundus autofluorescence images of 120 eyes (109 patients) with incident GA and at least 2 years of preceding FAF images. Methods: Images of incident GA were stacked and aligned over FAF images of preceding annual visits. The regions of retina where incident GA developed were assessed on prior years’ FAF images. These regions, defined as precursor lesions, were classified into minimal change autofluorescence, predominant hypoautofluorescence (decreased autofluorescence), predominant hyperautofluorescence (increased autofluorescence), and mixed autofluorescence. The natural progression in precursor lesions leading to GA formation and their associations with incident GA size and GA enlargement rate were evaluated. Main Outcome Measures: Incident GA area and enlargement rate and precursor pattern frequency. Results: Incident GA had a mean area of 1.00 mm2 (range, 0.15–8.22 mm2) and an enlargement rate of 0.97 mm2/year (standard deviation, 1.66 mm2/year). Predominant hypoautofluorescence was the most common precursor lesion, increasing from 42% to 81% over 3 years before onset of GA. Almost 30% of eyes showed minimal change autofluorescence 3 years before GA. Among the other precursors, 70% progressed to predominant hypoautofluorescence before GA developed. The type of precursor lesions was not associated with incident GA area. Geographic atrophy evolving from minimal change autofluorescence precursor lesions was associated with faster GA enlargement rates compared with other precursor lesion classes. Conclusions: Using image registration, we identified changes in autofluorescence images before the onset of GA. Decreased autofluorescence was the most common change, although minimal changes also were seen in one third of the images. Incident GA that arises from predominantly normal autofluorescence is associated with faster enlargement rates compared with GA arising from abnormal autofluorescence. Faster GA enlargement rates also were associated with incident GA size, area of surround abnormal autofluorescence, and presence of reticular pseudodrusen.

Original languageEnglish (US)
Pages (from-to)724-733
Number of pages10
JournalOphthalmology Retina
Volume3
Issue number9
DOIs
StatePublished - Sep 1 2019

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Geographic Atrophy
Eye Diseases
Optical Imaging

ASJC Scopus subject areas

  • Ophthalmology

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Precursors and Development of Geographic Atrophy with Autofluorescence Imaging : Age-Related Eye Disease Study 2 Report Number 18. / Age-Related Eye Disease Study 2 Research Group.

In: Ophthalmology Retina, Vol. 3, No. 9, 01.09.2019, p. 724-733.

Research output: Contribution to journalArticle

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title = "Precursors and Development of Geographic Atrophy with Autofluorescence Imaging: Age-Related Eye Disease Study 2 Report Number 18",
abstract = "Purpose: To describe the sequence of events leading to development of geographic atrophy (GA) in age-related macular degeneration with fundus autofluorescence (FAF) imaging. Design: Post hoc analysis of FAF images from the Age-Related Eye Disease Study 2. Participants: Fundus autofluorescence images of 120 eyes (109 patients) with incident GA and at least 2 years of preceding FAF images. Methods: Images of incident GA were stacked and aligned over FAF images of preceding annual visits. The regions of retina where incident GA developed were assessed on prior years’ FAF images. These regions, defined as precursor lesions, were classified into minimal change autofluorescence, predominant hypoautofluorescence (decreased autofluorescence), predominant hyperautofluorescence (increased autofluorescence), and mixed autofluorescence. The natural progression in precursor lesions leading to GA formation and their associations with incident GA size and GA enlargement rate were evaluated. Main Outcome Measures: Incident GA area and enlargement rate and precursor pattern frequency. Results: Incident GA had a mean area of 1.00 mm2 (range, 0.15–8.22 mm2) and an enlargement rate of 0.97 mm2/year (standard deviation, 1.66 mm2/year). Predominant hypoautofluorescence was the most common precursor lesion, increasing from 42{\%} to 81{\%} over 3 years before onset of GA. Almost 30{\%} of eyes showed minimal change autofluorescence 3 years before GA. Among the other precursors, 70{\%} progressed to predominant hypoautofluorescence before GA developed. The type of precursor lesions was not associated with incident GA area. Geographic atrophy evolving from minimal change autofluorescence precursor lesions was associated with faster GA enlargement rates compared with other precursor lesion classes. Conclusions: Using image registration, we identified changes in autofluorescence images before the onset of GA. Decreased autofluorescence was the most common change, although minimal changes also were seen in one third of the images. Incident GA that arises from predominantly normal autofluorescence is associated with faster enlargement rates compared with GA arising from abnormal autofluorescence. Faster GA enlargement rates also were associated with incident GA size, area of surround abnormal autofluorescence, and presence of reticular pseudodrusen.",
author = "{Age-Related Eye Disease Study 2 Research Group} and Holmen, {Ian C.} and Bryce Aul and Pak, {Jeong W.} and Trane, {Ralph Moeller} and Barbara Blodi and Michael Klein and Traci Clemons and Emily Chew and Amitha Domalpally",
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AU - Age-Related Eye Disease Study 2 Research Group

AU - Holmen, Ian C.

AU - Aul, Bryce

AU - Pak, Jeong W.

AU - Trane, Ralph Moeller

AU - Blodi, Barbara

AU - Klein, Michael

AU - Clemons, Traci

AU - Chew, Emily

AU - Domalpally, Amitha

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N2 - Purpose: To describe the sequence of events leading to development of geographic atrophy (GA) in age-related macular degeneration with fundus autofluorescence (FAF) imaging. Design: Post hoc analysis of FAF images from the Age-Related Eye Disease Study 2. Participants: Fundus autofluorescence images of 120 eyes (109 patients) with incident GA and at least 2 years of preceding FAF images. Methods: Images of incident GA were stacked and aligned over FAF images of preceding annual visits. The regions of retina where incident GA developed were assessed on prior years’ FAF images. These regions, defined as precursor lesions, were classified into minimal change autofluorescence, predominant hypoautofluorescence (decreased autofluorescence), predominant hyperautofluorescence (increased autofluorescence), and mixed autofluorescence. The natural progression in precursor lesions leading to GA formation and their associations with incident GA size and GA enlargement rate were evaluated. Main Outcome Measures: Incident GA area and enlargement rate and precursor pattern frequency. Results: Incident GA had a mean area of 1.00 mm2 (range, 0.15–8.22 mm2) and an enlargement rate of 0.97 mm2/year (standard deviation, 1.66 mm2/year). Predominant hypoautofluorescence was the most common precursor lesion, increasing from 42% to 81% over 3 years before onset of GA. Almost 30% of eyes showed minimal change autofluorescence 3 years before GA. Among the other precursors, 70% progressed to predominant hypoautofluorescence before GA developed. The type of precursor lesions was not associated with incident GA area. Geographic atrophy evolving from minimal change autofluorescence precursor lesions was associated with faster GA enlargement rates compared with other precursor lesion classes. Conclusions: Using image registration, we identified changes in autofluorescence images before the onset of GA. Decreased autofluorescence was the most common change, although minimal changes also were seen in one third of the images. Incident GA that arises from predominantly normal autofluorescence is associated with faster enlargement rates compared with GA arising from abnormal autofluorescence. Faster GA enlargement rates also were associated with incident GA size, area of surround abnormal autofluorescence, and presence of reticular pseudodrusen.

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