Preconditioning and postconditioning for neuroprotection: The most recent evidence

Stacy L. Fairbanks, Ansgar M. Brambrink

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Stroke is a leading cause of morbidity and mortality, with perioperative stroke being an important complication in the practice of anaesthesia. Unfortunately, pharmacological treatment options are very limited and often not applicable in the perioperative period. The notion of applying a subtoxic stimulus prior to an otherwise lethal event is termed preconditioning. The main focus of the article is on describing the different concepts of preconditioning, including remote ischaemic preconditioning and anaesthetic preconditioning, as well as postconditioning and summarizing the most recent discoveries in this exciting field.

Original languageEnglish (US)
Pages (from-to)521-534
Number of pages14
JournalBest Practice and Research: Clinical Anaesthesiology
Volume24
Issue number4
DOIs
StatePublished - Dec 1 2010

Keywords

  • Anaesthesia
  • Anaesthetic
  • Remote ischaemic postconditioning
  • Stroke, ischaemia, preconditioning, postconditioning

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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