TY - JOUR
T1 - Preconditioning and postconditioning for neuroprotection
T2 - The most recent evidence
AU - Fairbanks, Stacy L.
AU - Brambrink, Ansgar M.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2010/12
Y1 - 2010/12
N2 - Stroke is a leading cause of morbidity and mortality, with perioperative stroke being an important complication in the practice of anaesthesia. Unfortunately, pharmacological treatment options are very limited and often not applicable in the perioperative period. The notion of applying a subtoxic stimulus prior to an otherwise lethal event is termed preconditioning. The main focus of the article is on describing the different concepts of preconditioning, including remote ischaemic preconditioning and anaesthetic preconditioning, as well as postconditioning and summarizing the most recent discoveries in this exciting field.
AB - Stroke is a leading cause of morbidity and mortality, with perioperative stroke being an important complication in the practice of anaesthesia. Unfortunately, pharmacological treatment options are very limited and often not applicable in the perioperative period. The notion of applying a subtoxic stimulus prior to an otherwise lethal event is termed preconditioning. The main focus of the article is on describing the different concepts of preconditioning, including remote ischaemic preconditioning and anaesthetic preconditioning, as well as postconditioning and summarizing the most recent discoveries in this exciting field.
KW - Anaesthesia
KW - Anaesthetic
KW - Remote ischaemic postconditioning
KW - Stroke, ischaemia, preconditioning, postconditioning
UR - http://www.scopus.com/inward/record.url?scp=78649671280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649671280&partnerID=8YFLogxK
U2 - 10.1016/j.bpa.2010.10.004
DO - 10.1016/j.bpa.2010.10.004
M3 - Review article
C2 - 21619864
AN - SCOPUS:78649671280
SN - 1753-3740
VL - 24
SP - 521
EP - 534
JO - Bailliere's Best Practice and Research in Clinical Anaesthesiology
JF - Bailliere's Best Practice and Research in Clinical Anaesthesiology
IS - 4
ER -