Precision medicine: Clarity for the complexity of dementia

Brenna Cholerton, Eric B. Larson, Joseph Quinn, Cyrus P. Zabetian, Ignacio F. Mata, C. Dirk Keene, Margaret Flanagan, Paul K. Crane, Thomas J. Grabowski, Kathleen S. Montine, Thomas J. Montine

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

Original languageEnglish (US)
Pages (from-to)500-506
Number of pages7
JournalAmerican Journal of Pathology
Volume186
Issue number3
DOIs
StatePublished - Mar 1 2016

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Precision Medicine
Dementia
Rare Diseases
Parkinson Disease
Alzheimer Disease
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cholerton, B., Larson, E. B., Quinn, J., Zabetian, C. P., Mata, I. F., Keene, C. D., ... Montine, T. J. (2016). Precision medicine: Clarity for the complexity of dementia. American Journal of Pathology, 186(3), 500-506. https://doi.org/10.1016/j.ajpath.2015.12.001

Precision medicine : Clarity for the complexity of dementia. / Cholerton, Brenna; Larson, Eric B.; Quinn, Joseph; Zabetian, Cyrus P.; Mata, Ignacio F.; Keene, C. Dirk; Flanagan, Margaret; Crane, Paul K.; Grabowski, Thomas J.; Montine, Kathleen S.; Montine, Thomas J.

In: American Journal of Pathology, Vol. 186, No. 3, 01.03.2016, p. 500-506.

Research output: Contribution to journalArticle

Cholerton, B, Larson, EB, Quinn, J, Zabetian, CP, Mata, IF, Keene, CD, Flanagan, M, Crane, PK, Grabowski, TJ, Montine, KS & Montine, TJ 2016, 'Precision medicine: Clarity for the complexity of dementia', American Journal of Pathology, vol. 186, no. 3, pp. 500-506. https://doi.org/10.1016/j.ajpath.2015.12.001
Cholerton, Brenna ; Larson, Eric B. ; Quinn, Joseph ; Zabetian, Cyrus P. ; Mata, Ignacio F. ; Keene, C. Dirk ; Flanagan, Margaret ; Crane, Paul K. ; Grabowski, Thomas J. ; Montine, Kathleen S. ; Montine, Thomas J. / Precision medicine : Clarity for the complexity of dementia. In: American Journal of Pathology. 2016 ; Vol. 186, No. 3. pp. 500-506.
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