PRECIPITATION OF MYELIN BASIC PROTEIN BY β‐LIPOPROTEIN OF HUMAN SERUM: A study of similarities and differences of the precipitation in normal sera and sera from patients with multiple sclerosis

H. Offner, J. Clausen, T. Fog

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel‐precipitation among MS (32.5%) than among controls (11.5%). β‐lipoproteins isolated from all MS and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the occurrence of a precipitation blocking factor in the entire sera.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalActa Neurologica Scandinavica
Volume50
Issue number2
DOIs
StatePublished - Apr 1974

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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