Precipitation of myelin basic protein by β lipoprotein of human serum. A study of similarities and differences of the precipitation in normal sera and sera from patients with multiple sclerosis

Halina Offner, J. Clausen, T. Fog

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel precipitation among MS patients (32.5%) than among controls (11.5%). β lipoproteins isolated from all MS patients and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the presence of a precipitation blocking factor in the entire sera.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalActa Neurologica Scandinavica
Volume50
Issue number2
StatePublished - 1974
Externally publishedYes

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Lipoproteins
Multiple Sclerosis
Serum
Myelin Basic Protein
human MBP protein
Gels

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

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abstract = "Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel precipitation among MS patients (32.5{\%}) than among controls (11.5{\%}). β lipoproteins isolated from all MS patients and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the presence of a precipitation blocking factor in the entire sera.",
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AU - Offner, Halina

AU - Clausen, J.

AU - Fog, T.

PY - 1974

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N2 - Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel precipitation among MS patients (32.5%) than among controls (11.5%). β lipoproteins isolated from all MS patients and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the presence of a precipitation blocking factor in the entire sera.

AB - Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel precipitation among MS patients (32.5%) than among controls (11.5%). β lipoproteins isolated from all MS patients and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the presence of a precipitation blocking factor in the entire sera.

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