PRECIPITATION OF MYELIN BASIC PROTEIN BY β‐LIPOPROTEIN OF HUMAN SERUM: A study of similarities and differences of the precipitation in normal sera and sera from patients with multiple sclerosis

H. Offner; J. Clausen; T. Fog

doi:10.1111/j.1600-0404.1974.tb02773.x

PRECIPITATION OF MYELIN BASIC PROTEIN BY β‐LIPOPROTEIN OF HUMAN SERUM: A study of similarities and differences of the precipitation in normal sera and sera from patients with multiple sclerosis

H. Offner, J. Clausen, T. Fog

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel‐precipitation among MS (32.5%) than among controls (11.5%). β‐lipoproteins isolated from all MS and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the occurrence of a precipitation blocking factor in the entire sera.

Original language	English (US)
Pages (from-to)	221-226
Number of pages	6
Journal	Acta Neurologica Scandinavica
Volume	50
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0404.1974.tb02773.x
State	Published - Apr 1974
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1600-0404.1974.tb02773.x

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PRECIPITATION OF MYELIN BASIC PROTEIN BY β‐LIPOPROTEIN OF HUMAN SERUM: A study of similarities and differences of the precipitation in normal sera and sera from patients with multiple sclerosis. / Offner, H.; Clausen, J.; Fog, T.
In: Acta Neurologica Scandinavica, Vol. 50, No. 2, 04.1974, p. 221-226.

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AB - Precipitation of myelin basic protein by sera from MS patients and controls was studied. The experiments with whole sera revealed a higher frequency of the positive gel‐precipitation among MS (32.5%) than among controls (11.5%). β‐lipoproteins isolated from all MS and control sera were demonstrated to link to myelin basic protein giving rise to a single precipitation line in the immunoelectrophoretic system. The lipoprotein pattern of MS sera was quantitatively and qualitatively identical to that of control sera. The results suggest the occurrence of a precipitation blocking factor in the entire sera.

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PRECIPITATION OF MYELIN BASIC PROTEIN BY β‐LIPOPROTEIN OF HUMAN SERUM: A study of similarities and differences of the precipitation in normal sera and sera from patients with multiple sclerosis

Abstract

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