Precancerous conditions of gallbladder carcinoma: Overview of histopathologic characteristics and molecular genetic findings

Eizaburo Sasatomi, Osamu Tokunaga, Kohji Miyazaki

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Two distinct epithelial lesions (dysplasia and adenoma) and one high-risk condition (anomalous pancreatico-biliary ductal junction; APBDJ) are currently recognized as premalignant stages of gallbladder carcinogenesis. In addition to clinicopathologic observations, recent molecular genetic studies have provided further insight into the pathogenesis and biological behavior of these precursor lesions. In this review, we concentrate on describing the histopathologic and clinicopathologic background and recent molecular genetic findings for each of these putative precursor lesions.

Original languageEnglish (US)
Pages (from-to)556-567
Number of pages12
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume7
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Adenoma
  • Anomalous pancreatico-biliary ductal junction
  • Dysplasia
  • Gallbladder carcinoma
  • Precancerous condition

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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