Preabsorptive vs. postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice

J. K. Belknap, N. D. Belknap, J. H. Berg, R. Coleman

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Experimentally naive male mice of both strains were exposed to a two-bottle choice situation (ethanol vs. water) and their drinking behavior was observed during the first hour. DBA/2J mice developed a significant avoidance of 2% or 10% ethanol during the first 10 min. At 15 and 60 min following introduction of the bottles, no DBA mouse exhibited more than a 6 mg % blood ethanol level while all of the C57BL mice exceeded this concentration. Significant postabsorptive effects in the DBA mice seem unlikely at these very low blood ethanol values. Animals of both strains were examined for their ability to form lithium-induced conditioned taste aversions to 2% ethanol or 15% sucrose solutions. DBA mice readily formed conditioned aversions to both solutions, but the C57BL strain significantly avoided only the sucrose. C57BL mice appear to have difficulty in discriminating the 2% ethanol from distilled water. The neural sensitivity to ethanol was examined in both strains using the sleep time test and the grid test. C57BL mice were significantly more sensitive than DBA mice in both tests.

Original languageEnglish (US)
Pages (from-to)413-425
Number of pages13
JournalBehavior genetics
Volume7
Issue number6
DOIs
StatePublished - Nov 1 1977

Keywords

  • C57BL and DBA mice
  • alcohol (ethanol) preference
  • lithium-induced conditioned aversion
  • sleep time test

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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