Pre-sympathetic neurones in the rostral ventrolateral medulla of the rat: Electrophysiology, morphology and relationship to adjacent neuronal groups

Janusz Lipski, Refik Kanjhan, Barbara Kruszewska, Weifang F. Rong, M (Susan) Smith

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The activity of preganglionic sympathetic neurones largely depends on synaptic excitation from antecendent reticulospinal neurones located in the rostral ventrolateral medulla (RVLM). Our study, conducted in anaesthetized rats, showed that all RVLM pre-sympathetic neurones display a substantial synaptic noise and their action potentials are usually preceded by fast EPSPs. No evidence was found for presence of gradual depolarizations (autodepolarizations) between individual spikes. Therefore our results are consistent with the 'network' hypothesis for the generation of sympathetic vasomotor tone. Axons of some pre-sympathetic neurones intracellularly labelled with Neurobiotin or Lucifer Yellow had collaterals arborizing in several medullary regions. Thus these neurones have synaptic inputs not only to preganglionic sympathetic neurones, but also to other, yet unidentified cells in the brainstem. Finally, our results show that anatomically adjacent RVLM pre-sympathetic and Botzinger respiratory neurones from two functionally distinct neuronal subpopulations, and that some pre-sympathetic neurones have an adrenergic phenotype.

Original languageEnglish (US)
Pages (from-to)373-384
Number of pages12
JournalActa Neurobiologiae Experimentalis
Volume56
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Electrophysiology
Neurons
Adrenergic Neurons
Excitatory Postsynaptic Potentials
Action Potentials
Brain Stem
Axons
Noise
Phenotype

Keywords

  • brainstem
  • cardiovascular control
  • immunocytochemistry
  • in vivo
  • intracellular recording

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pre-sympathetic neurones in the rostral ventrolateral medulla of the rat : Electrophysiology, morphology and relationship to adjacent neuronal groups. / Lipski, Janusz; Kanjhan, Refik; Kruszewska, Barbara; Rong, Weifang F.; Smith, M (Susan).

In: Acta Neurobiologiae Experimentalis, Vol. 56, No. 1, 1996, p. 373-384.

Research output: Contribution to journalArticle

Lipski, Janusz ; Kanjhan, Refik ; Kruszewska, Barbara ; Rong, Weifang F. ; Smith, M (Susan). / Pre-sympathetic neurones in the rostral ventrolateral medulla of the rat : Electrophysiology, morphology and relationship to adjacent neuronal groups. In: Acta Neurobiologiae Experimentalis. 1996 ; Vol. 56, No. 1. pp. 373-384.
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