Pre-ovulatory events in the rhesus monkey follicle during ovulation induction.

    Research output: Contribution to journalArticle

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    Abstract

    Pituitary gonadotrophins, notably LH, and ovarian steroids, such as progesterone, play essential roles in the events leading to ovulation of the mature follicle and development of the subsequent corpus luteum. Rhesus monkeys (Macaca mulatta) undergoing controlled ovarian stimulation cycles comparable to those in clinical IVF/assisted reproduction treatment protocols provide a non-human primate model for studying peri-ovulatory events. The ability to manipulate the intrafollicular steroid milieu, via oral administration of a steroid synthesis inhibitor, with or without steroid replacement, allows one to distinguish between gonadotrophin-initiated, steroid-dependent versus steroid-independent processes. The length of the peri-ovulatory interval (onset of the LH surge to follicle rupture) is long (36-40 h) in primates and can be considered in terms of early (<or = 12 h) versus later (> or = 24 h) events. Granulosa cells lose their proliferative activity and differentiate into progesterone-secreting cells during the early peri-ovulatory interval. The rapid increase in progesterone synthetic capacity and expression of progesterone receptors suggests that this steroid has early actions, e.g. in controlling cell cycle machinery or differentiation. However, it is not until later that morphological luteinization is evident. By this stage, progesterone may serve as a potent anti-apoptotic factor and regulator of tissue remodelling through control of protease expression and activity, angiogenesis, or other events. Application of modern techniques to study LH- and progesterone-responsive gene expression will further unravel ovulatory and luteinization processes in specific compartments of the primate follicle.

    Original languageEnglish (US)
    Pages (from-to)1-4
    Number of pages4
    JournalReproductive BioMedicine Online
    Volume4 Suppl 3
    StatePublished - 2002

    Fingerprint

    Ovulation Induction
    Macaca mulatta
    Steroids
    Progesterone
    Luteinization
    Primates
    Pituitary Gonadotropins
    Granulosa Cells
    Corpus Luteum
    Thromboplastin
    Progesterone Receptors
    Menstrual Cycle
    Clinical Protocols
    Ovulation
    Gonadotropins
    Reproduction
    Oral Administration
    Rupture
    Cell Differentiation
    Cell Cycle

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    Pre-ovulatory events in the rhesus monkey follicle during ovulation induction. / Stouffer, Richard.

    In: Reproductive BioMedicine Online, Vol. 4 Suppl 3, 2002, p. 1-4.

    Research output: Contribution to journalArticle

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