38 patients with prostatic cancer who received breast irradiation before oral estrogen administration were studied. The data are combined with those from other institutions to determine the effectiveness of pre-estrogen breast irradiation in minimizing gynecomastia and/or pain. Based on the review the incidence of estrogen-induced breast changes is 70 per cent. Irradiation given before estrogen administration can prevent or minimize these changes in 89.3 per cent of the treated patients. Histologic changes of gynecomastia are reviewed and recommendations for optimum radiation therapy technique are included.
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