Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: Results from the SEARCH database

Katharine N. Sourbeer, Lauren E. Howard, Daniel M. Moreira, Hiruni S. Amarasekara, Lydia D. Chow, Dillon C. Cockrell, Brian T. Hanyok, Connor L. Pratson, Christopher J. Kane, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher Amling, Rohini K. Hernandez, Stephen J. Freedland

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose We investigated imaging practice patterns in men with nonmetastatic (M0) castration resistant prostate cancer. Materials and Methods We analyzed data on 247 patients with documented M0 CRPC from the SEARCH database. Patients were selected regardless of primary treatment modality and all had a negative bone scan after a castration resistant prostate cancer diagnosis. Cox models were used to test associations of time to a second imaging test with several demographic and clinical factors. Results During a median followup of 29.0 months (IQR 12.9-43.5) after a post-castration resistant prostate cancer bone scan was negative, 190 patients (77%) underwent a second imaging test. On univariable analysis patients with higher prostate specific antigen (HR 1.13, p = 0.016), shorter prostate specific antigen doubling time (HR 0.79, p

Original languageEnglish (US)
Pages (from-to)1232-1238
Number of pages7
JournalJournal of Urology
Volume193
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Castration
Prostatic Neoplasms
Databases
Bone and Bones
Prostate-Specific Antigen
Bone Neoplasms
Proportional Hazards Models
Demography
Therapeutics

Keywords

  • neoplasm metastasis
  • physician's practice patterns
  • prostate specific antigen
  • prostatic neoplasms
  • radionuclide imaging

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Sourbeer, K. N., Howard, L. E., Moreira, D. M., Amarasekara, H. S., Chow, L. D., Cockrell, D. C., ... Freedland, S. J. (2015). Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: Results from the SEARCH database. Journal of Urology, 193(4), 1232-1238. https://doi.org/10.1016/j.juro.2014.11.014

Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer : Results from the SEARCH database. / Sourbeer, Katharine N.; Howard, Lauren E.; Moreira, Daniel M.; Amarasekara, Hiruni S.; Chow, Lydia D.; Cockrell, Dillon C.; Hanyok, Brian T.; Pratson, Connor L.; Kane, Christopher J.; Terris, Martha K.; Aronson, William J.; Cooperberg, Matthew R.; Amling, Christopher; Hernandez, Rohini K.; Freedland, Stephen J.

In: Journal of Urology, Vol. 193, No. 4, 01.04.2015, p. 1232-1238.

Research output: Contribution to journalArticle

Sourbeer, KN, Howard, LE, Moreira, DM, Amarasekara, HS, Chow, LD, Cockrell, DC, Hanyok, BT, Pratson, CL, Kane, CJ, Terris, MK, Aronson, WJ, Cooperberg, MR, Amling, C, Hernandez, RK & Freedland, SJ 2015, 'Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: Results from the SEARCH database', Journal of Urology, vol. 193, no. 4, pp. 1232-1238. https://doi.org/10.1016/j.juro.2014.11.014
Sourbeer, Katharine N. ; Howard, Lauren E. ; Moreira, Daniel M. ; Amarasekara, Hiruni S. ; Chow, Lydia D. ; Cockrell, Dillon C. ; Hanyok, Brian T. ; Pratson, Connor L. ; Kane, Christopher J. ; Terris, Martha K. ; Aronson, William J. ; Cooperberg, Matthew R. ; Amling, Christopher ; Hernandez, Rohini K. ; Freedland, Stephen J. / Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer : Results from the SEARCH database. In: Journal of Urology. 2015 ; Vol. 193, No. 4. pp. 1232-1238.
@article{548a722cee644213902f9b1b9c0e18b4,
title = "Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: Results from the SEARCH database",
abstract = "Purpose We investigated imaging practice patterns in men with nonmetastatic (M0) castration resistant prostate cancer. Materials and Methods We analyzed data on 247 patients with documented M0 CRPC from the SEARCH database. Patients were selected regardless of primary treatment modality and all had a negative bone scan after a castration resistant prostate cancer diagnosis. Cox models were used to test associations of time to a second imaging test with several demographic and clinical factors. Results During a median followup of 29.0 months (IQR 12.9-43.5) after a post-castration resistant prostate cancer bone scan was negative, 190 patients (77{\%}) underwent a second imaging test. On univariable analysis patients with higher prostate specific antigen (HR 1.13, p = 0.016), shorter prostate specific antigen doubling time (HR 0.79, p",
keywords = "neoplasm metastasis, physician's practice patterns, prostate specific antigen, prostatic neoplasms, radionuclide imaging",
author = "Sourbeer, {Katharine N.} and Howard, {Lauren E.} and Moreira, {Daniel M.} and Amarasekara, {Hiruni S.} and Chow, {Lydia D.} and Cockrell, {Dillon C.} and Hanyok, {Brian T.} and Pratson, {Connor L.} and Kane, {Christopher J.} and Terris, {Martha K.} and Aronson, {William J.} and Cooperberg, {Matthew R.} and Christopher Amling and Hernandez, {Rohini K.} and Freedland, {Stephen J.}",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.juro.2014.11.014",
language = "English (US)",
volume = "193",
pages = "1232--1238",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer

T2 - Results from the SEARCH database

AU - Sourbeer, Katharine N.

AU - Howard, Lauren E.

AU - Moreira, Daniel M.

AU - Amarasekara, Hiruni S.

AU - Chow, Lydia D.

AU - Cockrell, Dillon C.

AU - Hanyok, Brian T.

AU - Pratson, Connor L.

AU - Kane, Christopher J.

AU - Terris, Martha K.

AU - Aronson, William J.

AU - Cooperberg, Matthew R.

AU - Amling, Christopher

AU - Hernandez, Rohini K.

AU - Freedland, Stephen J.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Purpose We investigated imaging practice patterns in men with nonmetastatic (M0) castration resistant prostate cancer. Materials and Methods We analyzed data on 247 patients with documented M0 CRPC from the SEARCH database. Patients were selected regardless of primary treatment modality and all had a negative bone scan after a castration resistant prostate cancer diagnosis. Cox models were used to test associations of time to a second imaging test with several demographic and clinical factors. Results During a median followup of 29.0 months (IQR 12.9-43.5) after a post-castration resistant prostate cancer bone scan was negative, 190 patients (77%) underwent a second imaging test. On univariable analysis patients with higher prostate specific antigen (HR 1.13, p = 0.016), shorter prostate specific antigen doubling time (HR 0.79, p

AB - Purpose We investigated imaging practice patterns in men with nonmetastatic (M0) castration resistant prostate cancer. Materials and Methods We analyzed data on 247 patients with documented M0 CRPC from the SEARCH database. Patients were selected regardless of primary treatment modality and all had a negative bone scan after a castration resistant prostate cancer diagnosis. Cox models were used to test associations of time to a second imaging test with several demographic and clinical factors. Results During a median followup of 29.0 months (IQR 12.9-43.5) after a post-castration resistant prostate cancer bone scan was negative, 190 patients (77%) underwent a second imaging test. On univariable analysis patients with higher prostate specific antigen (HR 1.13, p = 0.016), shorter prostate specific antigen doubling time (HR 0.79, p

KW - neoplasm metastasis

KW - physician's practice patterns

KW - prostate specific antigen

KW - prostatic neoplasms

KW - radionuclide imaging

UR - http://www.scopus.com/inward/record.url?scp=84926418655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926418655&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2014.11.014

DO - 10.1016/j.juro.2014.11.014

M3 - Article

C2 - 25463986

AN - SCOPUS:84926418655

VL - 193

SP - 1232

EP - 1238

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 4

ER -