PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats

Hiroshi Takahashi, Jeffrey Kirsch, Kenji Hashimoto, Edythe D. London, Raymond C. Koehler, Richard J. Traystman

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background and Purpose: We tested the hypothesis that intravenous administration of the potent σ-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) during transient focal ischemia would decrease postischemic brain infarction volume in rats. Methods: Rats underwent intravascular focal ischemia for 2 hours followed by 22 hours of reperfusion. Halothane anesthesia was used only during initiation and cessation of ischemia. Rats received saline (n=10) or 1 μmol/kg per hour PPBP (n=10) by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion. Results: There was no difference between groups in blood pressure, arterial blood gas values, and body temperature. Triphenyltetrazolium-determined infarction volume of ipsilateral cerebral cortex (saline, 39±6%; PPBP, 21±7% of ipsilateral hemisphere; mean±SEM) and striatum (saline, 68±6% PPBP, 33±8% of ipsilateral striatum) was smaller in rats treated with PPBP than in rats treated with saline. Conclusions: These data indicate that σ-receptors may play an important role in the mechanism of injury both in cortex and striatum after 2 hours of transient focal ischemia in rats. Because PPBP afforded protection when administered at the end of ischemia and during reperfusion, σ-receptors may influence the progression of injury in ischemic border regions.

Original languageEnglish (US)
Pages (from-to)2120-2123
Number of pages4
JournalStroke
Volume27
Issue number11
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Brain Injuries
Ischemia
Reperfusion
Arterial Pressure
Brain Infarction
Wounds and Injuries
Halothane
Body Temperature
Intravenous Infusions
Intravenous Administration
Cerebral Cortex
Infarction
4-phenyl-1-(4-phenylbutyl)piperidine
Anesthesia
Gases
Ligands

Keywords

  • cerebral ischemia, focal
  • neuronal damage
  • rats
  • receptors, sigma

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Takahashi, H., Kirsch, J., Hashimoto, K., London, E. D., Koehler, R. C., & Traystman, R. J. (1996). PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke, 27(11), 2120-2123.

PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. / Takahashi, Hiroshi; Kirsch, Jeffrey; Hashimoto, Kenji; London, Edythe D.; Koehler, Raymond C.; Traystman, Richard J.

In: Stroke, Vol. 27, No. 11, 11.1996, p. 2120-2123.

Research output: Contribution to journalArticle

Takahashi, H, Kirsch, J, Hashimoto, K, London, ED, Koehler, RC & Traystman, RJ 1996, 'PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats', Stroke, vol. 27, no. 11, pp. 2120-2123.
Takahashi H, Kirsch J, Hashimoto K, London ED, Koehler RC, Traystman RJ. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996 Nov;27(11):2120-2123.
Takahashi, Hiroshi ; Kirsch, Jeffrey ; Hashimoto, Kenji ; London, Edythe D. ; Koehler, Raymond C. ; Traystman, Richard J. / PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. In: Stroke. 1996 ; Vol. 27, No. 11. pp. 2120-2123.
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